Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic
syndrome; its rising prevalence parallels the rise in obesity and diabetes. Historically …

Urate is a cause of gout, kidney stones, and acute kidney injury from tumor lysis syndrome,
but its relationship to kidney disease, cardiovascular disease, and diabetes remains …

The association between uric acid (UA) on one side and systemic hypertension (Htn),
dyslipidemia, glucose intolerance, overweight, fatty liver, renal disease and cardiovascular …

Uric acid, once viewed as an inert metabolic end-product of purine metabolism, has been
recently incriminated in a number of chronic disease states, including hypertension …

Calorie restriction (CR), a reduction of 10–40% in intake of a nutritious diet, is often reported
as the most robust non-genetic mechanism to extend lifespan and healthspan. CR is …

Excessive caloric intake in a form of high-fat diet (HFD) was long thought to be the major risk
factor for development of obesity and its complications, such as fatty liver disease and …

Metabolic syndrome represents a collection of abnormalities that includes fatty liver, and it
currently affects one-third of the United States population and has become a major health …

NAD+, a co-enzyme involved in a great deal of biochemical reactions, has been found to be
a network node of diverse biological processes. In mammalian cells, NAD+ is synthetized …

The intake of added sugars, such as from table sugar (sucrose) and high-fructose corn syrup
has increased dramatically in the last hundred years and correlates closely with the rise in …

High dietary fructose is a major contributor to insulin resistance and metabolic syndrome,
disturbing tissue and organ functions. Fructose is mainly absorbed into systemic circulation …