The immunosuppressive status of the tumor microenvironment (TME) remains poorly
defined due to a lack of understanding regarding the function of tumor-associated …

Tumor-associated macrophages (TAMs) are major innate immune cells that constitute up to
50% of the cell mass of human tumors. TAMs are highly heterogeneous cells that originate …

Breast cancer is presently the most predominant tumor type and the second leading cause
of tumor-related deaths among women. Although advancements in diagnosis and …

Tumor-associated macrophages (TAMs) as immune cells within the tumor microenvironment
have gained much interests as basic science regarding their roles in tumor progression …

Tumor-associated macrophages (TAMs) are important tumor-promoting cells in the breast
tumor microenvironment. Preclinically TAMs stimulate breast tumor progression, including …

Tumor-infiltrating lymphocytes (TILs) are infiltrating lymphocytes in tumor tissues. After
isolation, screening and amplification in vitro, they will be implanted into patients and play a …

The immune system plays a vital role in suppressing tumor cell progression. The tumor
microenvironment augmented with significant levels of tumor-infiltrating lymphocytes has …

Tumor associated macrophages (TAM) enhance the aggressiveness of breast cancer via
promoting cancer cell growth, metastasis, and suppression of the patient's immune system …

Triple-negative breast cancer (TNBC) is associated with a poor prognosis, due to its
aggressive behaviour and lack of effective targeted therapies. Immunocheckpoint inhibitors …

Macrophages are phagocytic sentinel cells of the immune system that are central to both
innate and adaptive immune responses and serve as the first line of defense against …