Metabolic syndrome (MetS) is a clinical manifestation characterized by a plethora of
comorbidities, including hyperglycemia, abdominal obesity, arterial hypertension, and …

Acetals and ketals and their nitrogen and sulfur homologues are often considered to be
unconventional and potentially problematic scaffolding elements or pharmacophores for the …

Despite the health benefits associated with the ingestion of the bioactive compounds in
cocoa, the high concentrations of polyphenols and methylxanthines in the raw cocoa beans …

Natural products have been studied to reveal new therapies against human dysfunctions
since they present several medicinal properties. Caffeine, theobromine and (+)-catechin are …

This case study on the model substance caffeine demonstrates the viability of a 10-step read-
across (RAX) framework in practice. New approach methodologies (NAM), including RAX …

It has been estimated that more than 70% of all drugs approved worldwide between 1981
and 2006 for human health are derived from or structurally similar to natural compounds …

Long-term stored oolong tea has recently attracted considerable attention concerning its
salutary effect. In this study, the anti-obesity effect of different years' oolong tea on high-fat …

Background Ovarian cancer (OC) is one of the worrisome gynecological cancers worldwide.
Given its considerable mortality rate, it is necessary to investigate its oncogenesis. Methods …

Alkaloids are a widespread group of secondary metabolites that occur naturally in a wide
range of plant families. Many of them exhibit significant biological activity and therefore have …

Natural medicinal compounds to treat obesity have recently attracted a great deal of
attention because of the serious side effects of synthetic anti-obesity drugs. Recent …