Bone is a dynamic tissue constantly responding to environmental changes such as
nutritional and mechanical stress. Bone homeostasis in adult life is maintained through bone …

Isolated cleft palate (CPO) is the rarest form of oral clefting. The incidence of CPO varies
substantially by geography from 1.3 to 25.3 per 10,000 live births, with the highest rates in …

Limited stem cells, poor stretchability and mismatched interface fusion have plagued the
reconstruction of cranial defects by cell-free scaffolds. Here, we designed an instantly fixable …

Bone tissue undergoes constant turnover supported by stem cells. Recent studies showed
that perivascular mesenchymal stem cells (MSCs) contribute to the turnover of long bones …

The tooth root is an integral, functionally important part of our dentition. The formation of a
functional root depends on epithelial-mesenchymal interactions and integration of the root …

Hayes' Principles and Methods of Toxicology has long been established as a reliable and
informative reference for the concepts, methodologies, and assessments integral to …

BMP signaling plays an important role in dentin development. BMPs and antagonists
regulate odontoblast differentiation and downstream gene expression via canonical Smad …

The suture mesenchyme serves as a growth centre for calvarial morphogenesis and has
been postulated to act as the niche for skeletal stem cells. Aberrant gene regulation causes …

Neural crest cells (NCCs) are multipotent stem cells that can differentiate into multiple cell
types, including the osteoblasts and chondrocytes, and constitute most of the craniofacial …

Craniosynostosis is a developmental craniofacial anomaly, resulting in impairment of brain
development and abnormally shaped skull. The main cause of craniosynostosis is …