Chronic obstructive pulmonary disease (COPD) is a global health issue with high social and
economic costs. Concomitant chronic cardiac disorders are frequent in patients with COPD …

Numerous drugs containing a cationic amphiphilic structure are capable of inducing
phospholipidosis in cells under conditions of in vivo administration or ex vivo incubation …

The development of drugs to combat diseases, chemicals to im prove food production, or
compounds to enhance the quality of life necessitates, by law, the use of laboratory animals …

Within drug development and pre-clinical trials, a common, significant and poorly
understood event is the development of drug-induced lipidosis in tissues and cells. In this …

Statins inhibit the 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase, reduce the serum
level of low-density lipoprotein cholesterol, and are extensively prescribed to prevent …

Amiodarone (AD) is a highly efficient antiarrhythmic drug with potentially serious side effects.
Severe pulmonary toxicity is reported in patients receiving AD even at low doses and may …

Amiodarone (AMD)-induced toxicity can be a life-threatening complication which limits the
use of amiodarone as an anti-arrhythmic agent. The aim of the present study was to …

Amiodarone (Am) pneumonitis is currently a common and potentially severe adverse
reaction, the accurate diagnosis of which remains difficult to establish. Objectives: To …

Amiodarone (AMD) is one of the most effective antiarrhythmic drugs available. However, its
use is often limited by side-effects, mainly hypo-or hyperthyroidism. As AMD displays direct …

Many therapeutic drugs currently in use are cationic amphiphiles. These cationic
amphiphilic drugs (CADs) induce phospholipidosis in humans and experimental animals …