Ferroptosis is an iron-and lipid reactive oxygen species (ROS)-dependent form of
programmed cell death that is distinct from other forms of regulatory cell death at the …

Protein tyrosine kinases (PTKs) are a class of proteins with tyrosine kinase activity that
phosphorylate tyrosine residues of critical molecules in signaling pathways. Their basal …

Pediatric low-grade gliomas (pLGG) show heterogeneous responses to MAPK inhibitors
(MAPKi) in clinical trials. Thus, more complex stratification biomarkers are needed to identify …

In-frame BRAF exon 12 deletions are increasingly identified in various tumor types. The
resultant BRAFΔβ3-αC oncoproteins usually lack five amino acids in the β3-αC helix linker …

Hepatocellular carcinoma (HCC) is a major histological subtype of primary liver cancer.
Ample evidence suggests that the pathological properties of HCC originate from hepatic …

Hepatocellular carcinoma (HCC) progression is closely related to pathological fibrosis,
which involves heterotypic intercellular interactions (HIIs) between liver cancer cells and …

Hepatocellular carcinoma (HCC) has long been a major global clinical problem as one of
the most common malignant tumours with a high rate of recurrence and mortality. Although …

Hepatocellular carcinoma (HCC) has constituted a significant health burden worldwide, and
patients with advanced HCC, which is stage C as defined by the Barcelona Clinic Liver …

The synchronous functioning and quality control of organelles ensure cell survival and
function and are essential for maintaining homeostasis. Prolonged exposure to stressors …

Introduction Hepatocellular carcinoma (HCC) is a major health problem worldwide with
limited systemic therapy options. Since the approval of sorafenib in 2008, no systemic …