Responsive biomaterials: optimizing control of cancer immunotherapy
Immunotherapy has emerged as an eminent and effective modality in the treatment of
cancer. However, current cancer immunotherapies lack spatial and temporal control …
cancer. However, current cancer immunotherapies lack spatial and temporal control …
Deciphering and advancing CAR T-cell therapy with single-cell sequencing technologies
S Huang, X Wang, Y Wang, Y Wang, C Fang, Y Wang… - Molecular Cancer, 2023 - Springer
Chimeric antigen receptor (CAR) T-cell therapy has made remarkable progress in cancer
immunotherapy, but several challenges with unclear mechanisms hinder its wide clinical …
immunotherapy, but several challenges with unclear mechanisms hinder its wide clinical …
CAR‐Aptamers Enable Traceless Enrichment and Monitoring of CAR‐Positive Cells and Overcome Tumor Immune Escape
H Zhou, T Abudureheman, WW Zheng… - Advanced …, 2024 - Wiley Online Library
Chimeric antigen receptor (CAR)‐positive cell therapy, specifically with anti‐CD19 CAR‐T
(CAR19‐T) cells, achieves a high complete response during tumor treatment for …
(CAR19‐T) cells, achieves a high complete response during tumor treatment for …
CAR T cells for treating autoimmune diseases
Autoimmune disorders occur when immune cells go wrong and attack the body's own
tissues. Currently, autoimmune disorders are largely treated by broad immunosuppressive …
tissues. Currently, autoimmune disorders are largely treated by broad immunosuppressive …
Engineering challenges and opportunities in autologous cellular cancer immunotherapy
The use of a patient's own immune or tumor cells, manipulated ex vivo, enables Ag-or
patient-specific immunotherapy. Despite some clinical successes, there remain significant …
patient-specific immunotherapy. Despite some clinical successes, there remain significant …
Model‐informed drug development of autologous CAR‐T cell therapy: Strategies to optimize CAR‐T cell exposure leveraging cell kinetic/dynamic modeling
Autologous Chimeric antigen receptor (CAR‐T) cell therapy has been highly successful in
the treatment of aggressive hematological malignancies and is also being evaluated for the …
the treatment of aggressive hematological malignancies and is also being evaluated for the …
Chimeric antigen receptor T cell therapy: a new emerging landscape in autoimmune rheumatic diseases
Chimeric antigen receptor T cell (CAR-T) therapy, an innovative immune cell therapy, has
revolutionized the treatment landscape of haematological malignancies. The past 2 years …
revolutionized the treatment landscape of haematological malignancies. The past 2 years …
Biomaterials to enhance adoptive cell therapy
N Eckman, A Nejatfard, R Cavet… - Nature Reviews …, 2024 - nature.com
Adoptive cell therapy (ACT) harnesses the capabilities of immune cells to fight complex
diseases such as cancer. Treatment with adoptive transfer of engineered cells has led to …
diseases such as cancer. Treatment with adoptive transfer of engineered cells has led to …
Bridging the gender gap in autoimmunity with T-cell–targeted biomaterials
Highlights•Autoimmune diseases impact more women than men and are underrepresented
in research.•Imbalance of T-cell populations is inherent to most autoimmune …
in research.•Imbalance of T-cell populations is inherent to most autoimmune …
Electrotransfer for nucleic acid and protein delivery
A Muralidharan, PE Boukany - Trends in Biotechnology, 2023 - cell.com
Electrotransfer of nucleic acids and proteins has become crucial in biotechnology for gene
augmentation and genome editing. This review explores the applications of electrotransfer …
augmentation and genome editing. This review explores the applications of electrotransfer …