Cuproptosis, a novel copper-induced cell death pathway, is linked to mitochondrial
respiration and mediated by protein lipoylation. The discovery of cuproptosis unfolds new …

Sepsis involves simultaneous hyperactivation of the immune system and immune paralysis,
leading to both organ dysfunction and increased susceptibility to secondary infections. Acute …

Krebs cycle intermediates traditionally link to oxidative phosphorylation whilst also making
key cell components. It is now clear that some of these metabolites also act as signals …

Itaconate has been recently recognized as an anti-inflammatory metabolite involved in the
pathogen–macrophage interface. Due to its weak electrophilicity, itaconate could modify …

Immune cells react to their environment by flexibly reprogramming intracellular metabolic
pathways that subsequently alter immune function, in a process called immunometabolism …

Mitochondria are important signalling organelles, and they dictate immunological fate. From
T cells to macrophages, mitochondria form the nexus of the various metabolic pathways that …

A growing number of findings highlight the crucial role of metabolic reprogramming in
macrophage activation. Metabolic pathways are closely interconnected and recent literature …

Characterized by the accumulation of somatic mutations in blood cell lineages, clonal
hematopoiesis of indeterminate potential (CHIP) is frequent in aging and involves the …

Nearly 130 years after the first insights into the existence of mitochondria, new
rolesassociated with these organelles continue to emerge. As essential hubs that dictate cell …

Neutrophils are critical in the host defense against Staphylococcus aureus, a major human
pathogen. However, even in the setting of a robust neutrophil response, S. aureus can …