Computational modeling of realistic cell membranes

SJ Marrink, V Corradi, PCT Souza, HI Ingolfsson… - Chemical …, 2019 - ACS Publications
Cell membranes contain a large variety of lipid types and are crowded with proteins,
endowing them with the plasticity needed to fulfill their key roles in cell functioning. The …

Omega-3 fatty acids and neurodegenerative diseases: new evidence in clinical trials

R Avallone, G Vitale, M Bertolotti - International journal of molecular …, 2019 - mdpi.com
A nutritional approach could be a promising strategy to prevent or slow the progression of
neurodegenerative diseases such as Parkinson's and Alzheimer's disease, since there is no …

Lipid–protein interactions are unique fingerprints for membrane proteins

V Corradi, E Mendez-Villuendas, HI Ingólfsson… - ACS central …, 2018 - ACS Publications
Cell membranes contain hundreds of different proteins and lipids in an asymmetric
arrangement. Our current understanding of the detailed organization of cell membranes …

New insights into targeting membrane lipids for cancer therapy

G Preta - Frontiers in cell and developmental biology, 2020 - frontiersin.org
Modulation of membrane lipid composition and organization is currently developing as an
effective therapeutic strategy against a wide range of diseases, including cancer. This field …

Cholesterol stiffening of lipid membranes

FT Doole, T Kumarage, R Ashkar, MF Brown - The Journal of Membrane …, 2022 - Springer
Biomembrane order, dynamics, and other essential physicochemical parameters are
controlled by cholesterol, a major component of mammalian cell membranes. Although …

May omega-3 fatty acid dietary supplementation help reduce severe complications in Covid-19 patients?

P Weill, C Plissonneau, P Legrand, V Rioux, R Thibault - Biochimie, 2020 - Elsevier
In around 10% of SARS-CoV-2 infected patients, coronavirus disease-2019 (Covid-19)
symptoms are complicated with a severe lung damage called Acute Respiratory Distress …

Lipid rafts as a therapeutic target: thematic review series: biology of lipid rafts

D Sviridov, N Mukhamedova, YI Miller - Journal of lipid research, 2020 - ASBMB
Lipid rafts regulate the initiation of cellular metabolic and signaling pathways by organizing
the pathway components in ordered microdomains on the cell surface. Cellular responses …

Alterations of lipid profile in COVID-19: a narrative review

A Rezaei, S Neshat, K Heshmat-Ghahdarijani - Current Problems in …, 2022 - Elsevier
The COVID-19 pandemic has led to over 100 million infections and over 3 million deaths
worldwide. Understanding its pathogenesis is crucial to guide prognostic and therapeutic …

The role of polyunsaturated fatty acids in the neurobiology of major depressive disorder and suicide risk

ME Sublette, FM Daray, L Ganança, SR Shaikh - Molecular psychiatry, 2024 - nature.com
Long-chain polyunsaturated fatty acids (LC-PUFAs) are obtained from diet or derived from
essential shorter-chain fatty acids, and are crucial for brain development and functioning …

Alteration in the lipid profile and the desaturases activity in patients with severe pneumonia by SARS-CoV-2

I Pérez-Torres, V Guarner-Lans, E Soria-Castro… - Frontiers in …, 2021 - frontiersin.org
The kidnapping of the lipid metabolism of the host's cells by severe acute respiratory
syndrome (SARS-CoV-2) allows the virus to transform the cells into optimal machines for its …