Since the first approval of a protein kinase inhibitor (PKI) by the Food and Drug
Administration (FDA) in 2001, 55 new PKIs have reached the market, and many inhibitors …

Cancer cells have unlimited replicative potential, insensitivity to growth-inhibitory signals,
evasion of apoptosis, cellular stress, and sustained angiogenesis, invasiveness and …

In order to analyze how a signal transduction network converts cellular inputs into cellular
outputs, ideally one would measure the dynamics of many signals within the network …

Hepatocellular carcinoma (HCC) is one of the leading causes of death from cancer in the
world. Recently, the effectiveness of new antiviral therapies and the HBV vaccine have …

Tyrosine phosphorylation (pTyr) plays a pivotal role in signal transduction and is commonly
dysregulated in cancer. As a result, profiling tumor pTyr levels may reveal therapeutic …

Amyotrophic lateral sclerosis is the most common degenerative disorder of motor neurons in
adults. As there is no cure, thousands of individuals who are alive at present will succumb to …

Abstract Protein kinase CSNK2 (CK2) is a pleiotropic serine/threonine kinase frequently
dysregulated in solid and hematologic malignancies. To consolidate a wide range of …

Mass spectrometry-based phosphoproteomics is becoming an essential methodology for the
study of global cellular signaling. Numerous bioinformatics resources are available to …

Simple Summary All cells within tissues and organ systems must communicate with each
other to ensure they function in a coordinated manner. One form of communication is …

The human genome encodes more than 500 protein kinases that work by transferring the γ-
phosphate group from ATP to serine, threonine, or tyrosine (Ser/Thr/Tyr) residues. Various …