Cardiovascular diseases create an important burden on the public health systems,
especially in the elderly, mostly because this group of patients frequently suffer from multiple …

Cardiovascular disease is the most common cause of death among diabetic patients
worldwide. Hence, cardiovascular wellbeing in diabetic patients requires utmost importance …

Cathepsin B (CTSB), a member of lysosomal cathepsin, is involved in cell autophagy and
apoptosis. We previously reported that CTSB increased cardiomyocyte apoptosis in mice …

Autophagy is a highly conserved bulk degradation mechanism that degrades damaged
organelles, aged proteins and intracellular contents to maintain the homeostasis of the …

Diabetic cardiomyopathy (DCM) is a serious complication of diabetes mellitus (DM).
However, the precise molecular mechanisms remain largely unclear, and it is still a …

Endoplasmic reticulum (ER) plays important roles in protein synthesis, protein folding and
modification, lipid biosynthesis, calcium storage, and detoxification. ER homeostasis is …

A simultaneous increase in the prevalence of diabetes mellitus (DM), a risk factor for
cardiovascular diseases (CVDs), has contributed to the escalation of CVD related …

Diabetic cardiomyopathy (DCM) is a pathophysiological condition induced by diabetes
mellitus that often causes heart failure (HF). However, their mechanistic relationships remain …

Diabetic cardiomyopathy (DCM) is a common complication of diabetes mellitus (DM),
resulting in high mortality. Myocardial fibrosis, cardiomyocyte apoptosis and inflammatory …

Sacubitril/Valsartan (sac/val) has improved clinical prognosis in patients affected by heart
failure (HF) with reduced ejection fraction (HFrEF). HF and type 2 diabetes mellitus (T2DM) …