Endothelial cells are, by number, one of the most abundant cell types in the heart and active
players in cardiac physiology and pathology. Coronary angiogenesis plays a vital role in …

Myocardial regeneration is the key to the functional recovery of ischemic heart.
Angiogenesis plays a pivotal role in myocardial regeneration by resetting a rejuvenation …

Background Apigenin can reduce cardiomyocyte hypertrophy by downregulating hypoxia
inducible factor-1 alpha (HIF-1α) expression. However, its effects on cardiac fibroblasts …

Preeclampsia is associated with increased cardiovascular long-term risk; however, the
underlying functional and structural mechanisms are unknown. We investigated maternal …

Cardiac fibrosis is a difficult clinical puzzle without effective therapy. Exosomes play an
important role in alleviating cardiac fibrosis via angiogenesis. This research aimed to assess …

Ethnopharmacological relevance The prevalence of cardiovascular diseases (CVDs) has
been increasing worldwide. Despite significant improvements in therapeutics and on-going …

Pathological vascular remodeling is observed in various cardiovascular diseases including
pulmonary hypertension (PH), a disease of unknown etiology that has been characterized …

Myocardial ischemia leads to cardiac fibrosis along with copper (Cu) loss. Cu repletion
diminishes myocardial fibrosis and improves cardiac function. The transformation of …

Angiogenesis is a key process allowing the formation of blood vessels. It is crucial for all the
tissues and organs, ensuring their function and growth. Angiogenesis is finely controlled by …

Short-chain acyl-CoA dehydrogenase (SCAD), the rate-limiting enzyme for fatty acid β-
oxidation, has a negative regulatory effect on pathological cardiac hypertrophy and fibrosis …