Synopsis: Midazolam 1 is a short-acting water-soluble benzodiazepine (at pH< 4), a
member of a new class of imidazobenzodiazepine derivatives. At physiological pH the drug …

Midazolam is a 1, 4‐benzodiazepine derivative with a unique chemical structure: depending
on environmental pH, the drug can produce highly water‐soluble salts (pH< 4) or exist in …

M onitored anesthesia care (MAC) has evolved from an era in which anesthesiologists were
asked to be available on a “stand-by” basis to provide monitoring and sedation during …

Objective: To discuss the approach to sedation of the mechanically ventilated patient. Data
Synthesis: Mechanically ventilated patients in the intensive care unit frequently require …

Background. Anterograde, but not retrograde, amnesia has been demonstrated following
midazolam administration. However, there have been no studies investigating whether or …

Although the administration of sedatives is a commonplace activity in the ICU, few
guidelines are available to aid the clinician in this practice. The first principle of sedative …

Background Given the potentially important effects that age and gender may have on
midazolam premedication, this study aimed at determining if these factors alter anxiety …

Benzodiazepines (BDZs) enhance GABA A receptor inhibition by direct actions on central
BDZ receptors (CBRs). Although some BDZs also bind mitochondrial receptors [translocator …

Benzodiazepine drugs (BZ) are used for anxiety, insomnia, and seizures. They worsen
memory, especially in large doses, but the mechanism of this action is uncertain. In …

Midazolam, a water-soluble benzodiazepine that is shorter-acting, more potent, and less
irritating to veins than diazepam, has been suggested for use for induction of anesthesia …