When a protein is covalently and irreversibly bound to DNA (ie, a DNA–protein cross-link
[DPC]), it may obstruct any DNA-based transaction, such as transcription and replication …

DNA is associated with proteins that are involved in its folding and transaction processes.
When cells are exposed to chemical cross-linking agents or free radical–generating ionizing …

Proteins that act on DNA, or are in close proximity to it, can become inadvertently
crosslinked to DNA and form highly toxic lesions, known as DNA-protein crosslinks (DPCs) …

DNA–protein crosslinks (DPCs) are toxic DNA lesions wherein a protein is covalently
attached to DNA. If not rapidly repaired, DPCs create obstacles that disturb DNA replication …

Plants orchestrate various DNA damage responses (DDRs) to overcome the deleterious
impacts of genotoxic agents on genetic materials. Ionizing radiation (IR) is widely used as a …

Ionizing radiation produces clustered DNA damage that contains two or more lesions in 10–
20 bp. It is believed that the complexity of clustered damage (ie, the number of lesions per …

Many environmental carcinogens cause DNA damage, which can result in mutations and
other alterations in genomic DNA if not repaired promptly. Because of the bulkiness of the …

DNA-protein crosslinks (DPCs) are deleterious DNA lesions that occur when proteins are
irreversibly covalently crosslinked to the DNA by the action of variety of agents like reactive …

We herein attempted to identify the lowest radiation dose causing molecular changes in the
living body. We investigated the effects of radiation in human cells, animals, and humans …

The emergence of new compounds during the past decade requires a high-throughput
screening method for toxicity assay. The stress-responsive whole-cell biosensor is a …