The exposome describes the totality of internal and external environmental exposures,
across the life course. Components of the exposome have been linked to an increased risk …

Exposure to ultraviolet (UV) radiation induces tumorigenesis of keratinocytes and leads to
melanoma. On a molecular level, UV generates transcription-blocking DNA lesions that …

DNA-protein crosslinks (DPCs) form when proteins covalently attach to DNA. It is estimated
that hundreds of DPCs form in our cells each day. Because these lesions are cytotoxic …

The integrity of DNA is constantly challenged by a huge variety of damaging agents. If not
repaired, damaged DNA can lead to severe diseases and cell death. Therefore, cells …

This publication reveals the regulation mechanism of SPRTN mediated by ubiquitin switch
during DPC repair. I performed the in vivo experiments to identify that USP7 is the …

More than 650,000 head and neck cancers are diagnosed each year worldwide. More than
90% of head and neck cancers are squamous cell carcinomas. Some of the main risk factors …

Thyroid gland tumours are a heterogeneous group of neoplasms that may virtually arise
from any of the different cell types that are present in the thyroid gland. Among malignant …

DBPs, also known as DNA-binding proteins, play a crucial role in the evolutionary and
genetic mechanisms of humans. Understanding the features of DNA-binding peptides might …

Cutaneous melanoma represents the most aggressive skin cancer due to its high invasive
and metastatic behavior. Despite the adoption of novel screening programs and the …

Регуляция циркадного ритма является лишь одной из многих функций мелатонина,
который также обладает иммуномодулирующим, противовоспалительным …