Messenger RNA (mRNA) is an emerging class of therapeutic agent for the prevention and
treatment of a wide range of diseases. The recent success of the two highly efficacious …

Epigenetics regulates gene expression and has been confirmed to play a critical role in a
variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease …

Glycans modify lipids and proteins to mediate inter-and intramolecular interactions across all
domains of life. RNA is not thought to be a major target of glycosylation. Here, we challenge …

RNA molecules are essential for cellular information transfer and gene regulation, and
RNAs have been implicated in many human diseases. Messenger and non-coding RNAs …

The first published description of therapeutic applications of antisense oligonucleotide
(ASO) technology occurred in the late 1970s and was followed by the founding of …

Long noncoding RNAs (lncRNAs) have emerged as significant players in almost every level
of gene function and regulation. Thus, characterizing the structures and interactions of …

Abstract N 6-methyladenosine (m 6 A) is the most prevalent internal modification of
eukaryotic mRNA. Very little is known of the function of m 6 A in the immune system or its …

Many biological processes are RNA-mediated, but higher-order structures for most RNAs
are unknown, which makes it difficult to understand how RNA structure governs function …

RNA structure has critical roles in processes ranging from ligand sensing to the regulation of
translation, polyadenylation and splicing,,,. However, a lack of genome-wide in vivo RNA …

RNA structure is intimately connected to each step of gene expression. Recent advances
have enabled transcriptome-wide maps of RNA secondary structure, called 'RNA …