Background Recently, the hallmarks of aging were updated to include dysbiosis, disabled
macroautophagy, and chronic inflammation. In particular, the low-grade chronic …

DNA methylation is an important epigenetic mechanism that regulates gene expression. To
date, most DNA methylation studies have focussed on CpG islands in the gene promoter …

Post-translational modifications (PTMs) have been proposed as a link between the oxidative
stress-inflammation-ageing trinity, thereby affecting several hallmarks of ageing …

Inflammation is a biological response involving immune cells, blood vessels and mediators
induced by endogenous and exogenous stimuli, such as pathogens, damaged cells or …

The constrained disorder principle (CDP) defines systems based on their degree of disorder
bounded by dynamic boundaries. The principle explains stochasticity in living and non-living …

Over a third of the human genome is comprised of repetitive sequences, including more than
a million short tandem repeats (STRs). While studies of the pathologic consequences of …

So far, the search for a cure for Alzheimer Disease (AD) has been unsuccessful. The only
approved drugs attenuate some symptoms, but do not halt the progress of this disease …

Background Hidradenitis suppurativa (HS) is a chronic, systemic, inflammatory skin
condition with elusive pathogenesis that affects therapeutic intervention directly. Objective …

Abstract Long INterspersed Element 1 (LINE-1 or L1) acts as a major remodeling force in
genome regulation and evolution. Accumulating evidence shows that virus infection impacts …

As the repository of genetic information, the cell nucleus must protect DNA integrity from
mechanical stresses. The nuclear lamina, which resides within the nuclear envelope (NE), is …