Genomic and transcriptomic studies of expression quantitative trait loci (eQTL) revealed that
SINE-VNTR-Alu (SVA) retrotransposon insertion polymorphisms (RIPs) within human …

As the repository of genetic information, the cell nucleus must protect DNA integrity from
mechanical stresses. The nuclear lamina, which resides within the nuclear envelope (NE), is …

Background Hidradenitis suppurativa (HS) is a chronic, systemic, inflammatory skin
condition with elusive pathogenesis that affects therapeutic intervention directly. Objective …

Abstract Long INterspersed Element 1 (LINE-1 or L1) acts as a major remodeling force in
genome regulation and evolution. Accumulating evidence shows that virus infection impacts …

A high level of homocysteine (Hcy) is associated with oxidative/ER stress, apoptosis, and
impairment of angiogenesis, whereas hydrogen sulfide (H2S) has been found to reverse this …

Background Promoter hypermethylation of tumour suppressor genes is frequently observed
during the malignant transformation of colorectal cancer (CRC). However, whether this …

Genetic information is not transmitted solely by DNA but by the epigenetics process.
Epigenetics describes molecular missing link pathways that could bridge the gap between …

Ten-eleven translocation (TET) enzymes iteratively oxidize 5-methylcytosine (5mC) to
generate 5-hydroxymethylcytosine (5hmC), 5-formylcytosine, and 5-carboxylcytosine to …

Like many intracellular pathogens, the protozoan parasite Toxoplasma gondii has evolved
sophisticated mechanisms to promote its transmission and persistence in a variety of hosts …

The control of non-coding repeated DNA by DNA methylation plays an important role in
genomic stability, contributing to health and healthy aging. Mind-body practices can elicit …