[HTML][HTML] Evaluation of intranasal delivery route of drug administration for brain targeting
F Erdő, LA Bors, D Farkas, Á Bajza, S Gizurarson - Brain research bulletin, 2018 - Elsevier
The acute or chronic drug treatments for different neurodegenerative and psychiatric
disorders are challenging from several aspects. The low bioavailability and limited brain …
disorders are challenging from several aspects. The low bioavailability and limited brain …
Midazolam: an essential palliative care drug
E Prommer - Palliative care and social practice, 2020 - journals.sagepub.com
Midazolam is a commonly used benzodiazepine in palliative care and is considered one of
the four essential drugs needed for the promotion of quality care in dying patients. Acting on …
the four essential drugs needed for the promotion of quality care in dying patients. Acting on …
Treatment of neonatal seizures: comparison of treatment pathways from 11 neonatal intensive care units
JC Keene, LA Morgan, NS Abend, SV Bates… - Pediatric …, 2022 - Elsevier
Objective Seizures are a common neonatal neurologic emergency. Many centers have
developed pathways to optimize management. We evaluated neonatal seizure management …
developed pathways to optimize management. We evaluated neonatal seizure management …
Metabolism and pharmacokinetics of morphine in neonates: A review
GM Pacifici - Clinics, 2016 - SciELO Brasil
Morphine is an agonist of the µ and k receptors, whose activation results in analgesia.
Morphine-like agonists act through the µ opioid receptors to cause pain relief, sedation …
Morphine-like agonists act through the µ opioid receptors to cause pain relief, sedation …
Intranasal therapies for acute seizures
R Kälviäinen - Epilepsy & Behavior, 2015 - Elsevier
Most seizure emergencies occur outside of the hospital, and there is a need for treatment
interventions that can be administered quickly and safely by nonclinical caregivers …
interventions that can be administered quickly and safely by nonclinical caregivers …
Pharmacotherapy for seizures in neonates with hypoxic ischemic encephalopathy
E Yozawitz, A Stacey, RM Pressler - Pediatric Drugs, 2017 - Springer
Seizures are common in neonates with moderate and severe hypoxic ischemic
encephalopathy (HIE) and are associated with worse outcomes, independent of HIE …
encephalopathy (HIE) and are associated with worse outcomes, independent of HIE …
Ontogeny of drug-metabolizing enzymes
Almost 50% of prescription drugs lack age-appropriate dosing guidelines and therefore are
used “off-label.” Only~ 10% drugs prescribed to neonates and infants have been studied for …
used “off-label.” Only~ 10% drugs prescribed to neonates and infants have been studied for …
Decoding the synaptic proteome with long-term exposure to midazolam during early development
The intensive use of anesthetic and sedative agents in the neonatal intensive care unit
(NICU) has raised controversial concerns about the potential neurodevelopmental risks …
(NICU) has raised controversial concerns about the potential neurodevelopmental risks …
Challenges associated with route of administration in neonatal drug delivery
MW Linakis, JK Roberts, AC Lala, MG Spigarelli… - Clinical …, 2016 - Springer
The administration of drugs to neonates poses significant challenges. The aim of this review
was to provide insight into some of these challenges and resolutions that may be …
was to provide insight into some of these challenges and resolutions that may be …
Anaesthetic management of paediatric patients undergoing electrophysiology study and ablation for supraventricular tachycardia: A focused narrative review
F Monaco, JDA Ursoleo, CC Lerose, G Barucco… - Journal of Clinical …, 2024 - Elsevier
Abstract Every year, 80,000–100,000 ablation procedures take place in the United States
and approximately 1% of these involve paediatric patients. As the paediatric population …
and approximately 1% of these involve paediatric patients. As the paediatric population …