Successful antibiotic therapy in the critically ill requires sufficient drug concentrations at the
site of infection that kill or suppress bacterial growth. The relationship between antibiotic …

Pseudomonas aeruginosa is characterized by a notable intrinsic resistance to antibiotics,
mainly mediated by the expression of inducible chromosomic β-lactamases and the …

Introduction This study aims to assess the association of piperacillin/tazobactam and
meropenem minimum inhibitory concentration (MIC) and beta-lactam resistance genes with …

Piperacillin-tazobactam (PTZ) is one of the most common antibiotics administered to
hospitalized patients. Its broad activity against gram-negative, gram-positive, and anaerobic …

Introduction: The pharmacokinetic/pharmacodynamic index determining β-lactam activity is
the percentage of the dosing interval (% T) during which their free serum concentration …

Introduction Therapeutic drug monitoring (TDM) is a useful tool to optimize antibiotic therapy.
Increasing interest in alternative dosing strategies of beta-lactam antibiotics, eg continuous …

Piperacillin-tazobactam is frequently used for empirical and targeted therapy of infections in
critically ill patients. Considerable pharmacokinetic (PK) variability is observed in critically ill …

Augmented renal clearance is commonly observed in septic patients and may result in
insufficient β-lactam serum concentrations. The aims of this study were to evaluate potential …

Background Piperacillin levels after standard dosing have been shown frequently to be
subtherapeutic, especially when renal clearance was augmented. Here, we aimed to …

Management of nosocomial pneumonia is frequently complicated by bacterial resistance.
Extended infusions of beta-lactams are increasingly being used to improve clinical …