Plaguing humans for more than two millennia, manifest on every continent studied, and with
more than one billion patients having an attack in any year, migraine stands as the sixth …

Objective The goal of this narrative review is to provide an overview of migraine
pathophysiology, with an emphasis on the role of calcitonin gene‐related peptide (CGRP) …

Migraine is a neurological disorder that manifests as a debilitating headache associated
with altered sensory perception. The neuropeptide calcitonin gene-related peptide (CGRP) …

Pain is ultimately a perceptual phenomenon. It is built from information gathered by
specialized pain receptors in tissue, modified by spinal and supraspinal mechanisms, and …

Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …

A Systems Neuroscience Approach to Migraine Page 1 Neuron Perspective A Systems
Neuroscience Approach to Migraine KC Brennan1,* and Daniela Pietrobon2,3,* 1Department …

Animal models have provided a growing body of information about the pathophysiology of
headaches and novel therapeutic targets. In recent years, experiments in awake animals …

Objective Migraine is a prevalent and disabling neurological disease. Its genesis is poorly
understood, and there remains unmet clinical need. We aimed to identify mechanisms and …

Introduction: The neuropeptide calcitonin gene-related peptide (CGRP) is recognized as a
critical player in migraine pathophysiology. Excitement has grown regarding CGRP because …

Migraine is one of the most prevalent and disabling neurovascular disorders worldwide.
However, despite the increase in awareness and research, the understanding of migraine …