[HTML][HTML] Engineered mesenchymal stem cell-derived extracellular vesicles: a state-of-the-art multifunctional weapon against Alzheimer's disease

T Yin, Y Liu, W Ji, J Zhuang, X Chen, B Gong, J Chu… - Theranostics, 2023 - ncbi.nlm.nih.gov
With the increase of population aging, the number of Alzheimer's disease (AD) patients is
also increasing. According to current estimates, approximately 11% of people over 65 suffer …

Mitochondrial extracellular vesicles–origins and roles

L Amari, M Germain - Frontiers in Molecular Neuroscience, 2021 - frontiersin.org
Extracellular vesicles (EVs) have emerged in the last decade as critical cell-to-cell
communication devices used to carry nucleic acids and proteins between cells. EV cargo …

Exosomal mRNAs for angiogenic–osteogenic coupled bone repair

Y Ma, L Sun, J Zhang, C Chiang, J Pan… - Advanced …, 2023 - Wiley Online Library
Regenerative medicine in tissue engineering often relies on stem cells and specific growth
factors at a supraphysiological dose. These approaches are costly and may cause severe …

Modification of lipid-based nanoparticles: An efficient delivery system for nucleic acid-based immunotherapy

C Zhang, Y Ma, J Zhang, JCT Kuo, Z Zhang, H Xie… - Molecules, 2022 - mdpi.com
Lipid-based nanoparticles (LBNPs) are biocompatible and biodegradable vesicles that are
considered to be one of the most efficient drug delivery platforms. Due to the prominent …

Optimization of extracellular vesicle isolation and their separation from lipoproteins by size exclusion chromatography

B Benayas, J Morales, C Egea… - Journal of …, 2023 - Wiley Online Library
Interest in the use of extracellular vesicles (EVs) as biomarkers of disease is rapidly growing.
However, one main unsolved issue in the EV field is finding a technique able to eliminate …

Genetically engineered cellular nanoparticles for biomedical applications

N Krishnan, FX Peng, A Mohapatra, RH Fang, L Zhang - Biomaterials, 2023 - Elsevier
In recent years, nanoparticles derived from cellular membranes have been increasingly
explored for the prevention and treatment of human disease. With their flexible design and …

Emerging role of extracellular vesicles and cellular communication in metastasis

A Forder, CY Hsing, J Trejo Vazquez, C Garnis - Cells, 2021 - mdpi.com
Communication between cancer cells and the surrounding stromal cells of the tumor
microenvironment (TME) plays a key role in promoting metastasis, which is the major cause …

Cancer immunotherapy and delivery system: an update

M Yang, OT Olaoba, C Zhang, ET Kimchi… - Pharmaceutics, 2022 - mdpi.com
With an understanding of immunity in the tumor microenvironment, immunotherapy turns out
to be a powerful tool in the clinic to treat many cancers. The strategies applied in cancer …

[HTML][HTML] Cellular and molecular basis of therapeutic approaches to breast cancer

M El-Tanani, AO Al Khatib, BO Al-Najjar, AK Shakya… - Cellular signalling, 2023 - Elsevier
In recent decades, there has been a significant amount of research into breast cancer, with
some important breakthroughs in the treatment of both primary and metastatic breast …

Surface-engineered extracellular vesicles in cancer immunotherapy

V Johnson, S Vasu, US Kumar, M Kumar - Cancers, 2023 - mdpi.com
Simple Summary Extracellular vesicles are small membranous particles secreted by cells.
Extracellular vesicles facilitate the transportation of biomolecules, such as protein, RNA, and …