The molecular mechanism underlying the promotion of wound healing by TGF-beta 1 is
incompletely understood. We report that TGF-beta 1 regulates the regenerative/migratory …

The basal layer of human epidermis is a heterogeneous population of proliferative and
differentiating cells that can be divided into at least three functionally discrete compartments …

We previously identified a 90-kD (GP90), collagen-binding, membrane glycoprotein, termed
extracellular matrix receptor III (ECMR III), that is homologous to the lymphocyte homing …

In this study, the putative laminin receptor function of the alpha 6 beta 4 integrin was
assessed. For this purpose, we used a human cell line, referred to as clone A, that was …

Adhesion of keratinocytes in a wound outgrowth to laminin 5 in the basement membrane via
integrins α6β4 and α3β1 is distinct from adhesion to dermal collagen via α2β1 or to …

Previously, we demonstrated that proteolytic processing within the globular domain of the α3
subunit of laminin-5 (LN5) converts LN5 from a cell motility-inducing factor to a protein …

Functional studies on the α6β4 integrin have focused primarily on its role in the organization
of hemidesmosomes, stable adhesive structures that associate with the intermediate …

We have examined integrin expression during the remodeling of the epidermis that takes
place during wound healing, using a suction blister model in which the epidermis is …

Recent studies with patients suffering from epidermolysis bullosa simplex associated with
muscular dystrophy and the targeted gene disruption in mice suggested that plectin, a …

Stable attachment of external epithelia to the basement membrane and underlying stroma is
mediated by transmembrane proteins such as the integrin alpha6beta4 and bullous …