In vitro binding assays and inhibition of cell adhesion with monoclonal antibodies have
implicated the integrin α3β1 as a receptor for a variety of extracellular ligands. However …

The interactions of cells with extracellular matrices is of fundamental importance in many
biological processes such as embryological development, would healing and the …

Type VII collagen, the major component of anchoring fibrils, consists of a central
collagenous triple-helical domain flanked by two noncollagenous, globular domains, NC1 …

Keratinocyte migration is an absolute requirement for correct epithelialization during the
process of wound healing. This process requires changes in extracellular matrix ligand …

To examine the function of the alpha 6 beta 4 integrin we have determined its ligand-binding
ability and overexpressed two potentially dominant negative mutant beta 4 subunits, lacking …

Carcinomas are characterized by invasion of malignant cells into the underlying connective
tissue and migration of malignant cells to form metastases at distant sites. These processes …

Two cytoplasmic variants of the alpha 6 integrin, alpha 6A and alpha 6B, have been
identified previously (Hogervorst, F., I. Kuikman, AG van Kessel, and A. Sonnenberg. 1991 …

The cytoplasmic domain of the integrin β4 subunit mediates both association with the
hemidesmosomal cytoskeleton and recruitment of the signaling adaptor protein Shc. To …

Acquired or inherited junctional epidermolysis bullosa are skin diseases characterized by a
separation between the epidermis and the dermis. In inherited nonlethal junctional …

Transmembrane proteins of the tetraspanin superfamily are associated with various
integrins and modulate their function. We performed mutagenesis analysis to establish …