Migrasomes, a new mode of intercellular communication

Y Jiang, X Liu, J Ye, Y Ma, J Mao, D Feng… - Cell Communication and …, 2023 - Springer
Migrasomes are newly discovered extracellular vesicles (EVs) that are formed in migrating
cells and mediate intercellular communication. However, their size, biological generation …

Migrasome: a new functional extracellular vesicle

X Zhang, L Yao, Y Meng, B Li, Y Yang, F Gao - Cell Death Discovery, 2023 - nature.com
Migrasome is a novel cellular organelle produced during cell migration, and its biogenesis
depends on the migration process. It is generated in a variety of cells such as immune cells …

The formation of migrasomes is initiated by the assembly of sphingomyelin synthase 2 foci at the leading edge of migrating cells

H Liang, X Ma, Y Zhang, Y Liu, N Liu, W Zhang… - Nature Cell …, 2023 - nature.com
The migrasome is an organelle of migrating cells with diverse physiological functions. How
migrasome formation is initiated is unknown. We found that sphingomyelin is enriched in …

[HTML][HTML] Two-photon synthetic aperture microscopy for minimally invasive fast 3D imaging of native subcellular behaviors in deep tissue

Z Zhao, Y Zhou, B Liu, J He, J Zhao, Y Cai, J Fan, X Li… - Cell, 2023 - cell.com
Holistic understanding of physio-pathological processes requires noninvasive 3D imaging in
deep tissue across multiple spatial and temporal scales to link diverse transient subcellular …

Localized, highly efficient secretion of signaling proteins by migrasomes

H Jiao, X Li, Y Li, Y Guo, X Hu, T Sho, Y Luo, J Wang… - Cell Research, 2024 - nature.com
Migrasomes, enriched with signaling molecules such as chemokines, cytokines and
angiogenic factors, play a pivotal role in the spatially defined delivery of these molecules …

Emerging diversity in extracellular vesicles and their roles in cancer

IS Sohal, AL Kasinski - Frontiers in Oncology, 2023 - frontiersin.org
Extracellular vesicles have undergone a paradigm shift from being considered as 'waste
bags' to being central mediators of cell-to-cell signaling in homeostasis and several …

Deep proteomic analysis of obstetric antiphospholipid syndrome by DIA-MS of extracellular vesicle enriched fractions

W Tian, D Shi, Y Zhang, H Wang, H Tang… - Communications …, 2024 - nature.com
Proteins in the plasma/serum mirror an individual's physiology. Circulating extracellular
vesicles (EVs) proteins constitute a large portion of the plasma/serum proteome. Thus, deep …

Hamburger-like biomimetic nutrient periosteum with osteoimmunomodulation, angio-/osteo-genesis capacity promoted critical-size bone defect repair

S Hao, D Zhou, F Wang, G Li, A Deng, X Ren… - Chemical Engineering …, 2024 - Elsevier
The periosteum is pivotal in bone repair, serving as a key facilitator for new bone formation
through its osteoimmunomodulation and neovascularization. However, autologous …

Migrasomes trigger innate immune activation and mediate transmission of senescence signals across human cells

X Liu, H Jiao, B Zhang, S Zhang, K Yan, J Qu… - Life …, 2023 - academic.oup.com
Aging is a complex and heterogeneous process, raising important questions about how
aging is differently impacted by underlying genetics and external factors. Recently …

[HTML][HTML] A review of the roles of specialized extracellular vesicles, migrasomes, and exosomes in normal cell physiology and disease

T Zheng, S Xu, J Xu - … Medical Journal of Experimental and Clinical …, 2023 - ncbi.nlm.nih.gov
Migrasomes are newly-discovered cellular organelle which are generated during cell
migration and released from cells as extracellular vesicles (EVs), first described in 2015 …