An inflammation-centric view of neurological disease: beyond the neuron
Inflammation is a complex biological response fundamental to how the body deals with
injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a …
injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a …
Chemokines in neuron–glial cell interaction and pathogenesis of neuropathic pain
Neuropathic pain resulting from damage or dysfunction of the nervous system is a highly
debilitating chronic pain state and is often resistant to currently available treatments. It has …
debilitating chronic pain state and is often resistant to currently available treatments. It has …
The role of the immune system in the generation of neuropathic pain
Persistent pain is a sequela of several neurological conditions with a primary immune basis,
such as Guillain-Barré syndrome and multiple sclerosis. Additionally, diverse forms of injury …
such as Guillain-Barré syndrome and multiple sclerosis. Additionally, diverse forms of injury …
Characterisation of immune and neuroinflammatory changes associated with chemotherapy-induced peripheral neuropathy
PGS Makker, SS Duffy, JG Lees, CJ Perera, RS Tonkin… - PloS one, 2017 - journals.plos.org
Chemotherapy-induced peripheral neuropathy (CIPN) and associated neuropathic pain is a
debilitating adverse effect of cancer treatment. Current understanding of the mechanisms …
debilitating adverse effect of cancer treatment. Current understanding of the mechanisms …
CXCL12/CXCR4 signal transduction in diseases and its molecular approaches in targeted-therapy
A Mousavi - Immunology Letters, 2020 - Elsevier
Chemokines are small molecules called “chemotactic cytokines” and regulate many
processes like leukocyte trafficking, homing of immune cells, maturation, cytoskeletal …
processes like leukocyte trafficking, homing of immune cells, maturation, cytoskeletal …
miRNA-23a/CXCR4 regulates neuropathic pain via directly targeting TXNIP/NLRP3 inflammasome axis
Z Pan, Q Shan, P Gu, XM Wang, LW Tai, M Sun… - Journal of …, 2018 - Springer
Abstract Background Chemokine CXC receptor 4 (CXCR4) in spinal glial cells has been
implicated in neuropathic pain. However, the regulatory cascades of CXCR4 in neuropathic …
implicated in neuropathic pain. However, the regulatory cascades of CXCR4 in neuropathic …
Macrophagic and microglial complexity after neuronal injury
F Mesquida-Veny, JA Del Río, A Hervera - Progress in neurobiology, 2021 - Elsevier
Central nervous system (CNS) injuries do not heal properly in contrast to normal tissue
repair, in which functional recovery typically occurs. The reason for this dichotomy in wound …
repair, in which functional recovery typically occurs. The reason for this dichotomy in wound …
Mast cells, glia and neuroinflammation: partners in crime?
SD Skaper, L Facci, P Giusti - Immunology, 2014 - Wiley Online Library
Glia and microglia in particular elaborate pro‐inflammatory molecules that play key roles in
central nervous system (CNS) disorders from neuropathic pain and epilepsy to …
central nervous system (CNS) disorders from neuropathic pain and epilepsy to …
Spatial and temporal activation of spinal glial cells: role of gliopathy in central neuropathic pain following spinal cord injury in rats
In the spinal cord, neuron and glial cells actively interact and contribute to neurofunction.
Surprisingly, both cell types have similar receptors, transporters and ion channels and also …
Surprisingly, both cell types have similar receptors, transporters and ion channels and also …
Microglia and mast cells: two tracks on the road to neuroinflammation
SD Skaper, P Giusti, L Facci - The FASEB Journal, 2012 - Wiley Online Library
One of the more important recent advances in neuroscience research is the understanding
that there is extensive communication between the immune system and the central nervous …
that there is extensive communication between the immune system and the central nervous …