Conspectus Contrast agents are used in approximately 40% of all magnetic resonance
imaging (MRI) procedures to improve the quality of the images based on the distribution and …

MRI contrast agents are required in the clinic to detect some pathologies, such as cancers.
Nevertheless, at the moment, only small extracellular and non-specific gadolinium …

As an essential metal ion and an efficient relaxation agent, Mn2+ holds a great promise to
replace Gd3+ in magnetic resonance imaging (MRI) contrast agent applications, if its stable …

Liver fibrogenesis is accompanied by upregulation of lysyl oxidase enzymes, which catalyze
oxidation of lysine ε-amino groups on the extracellular matrix proteins to form the aldehyde …

While MnII complexes meet increasing interest in biomedical applications, ligands are
lacking that enable high MnII complex stability and selectivity vs. ZnII, the most relevant …

Detecting the fluctuation and distribution of various bioactive species in biological systems is
of great importance in determining diseases at their early stages. Metal complex-based …

We report the Mn (II) complexes with two pyclen-based ligands (pyclen= 3, 6, 9, 15-
tetraazabicyclo [9.3. 1] pentadeca-1 (15), 11, 13-triene) functionalized with acetate pendant …

Five amphiphilic, anionic Mn (II) complexes were synthesized as contrast agents targeted to
organic anion transporting polypeptide transporters (OATP) for liver magnetic resonance …

Imaging plays a pivotal role in the precise diagnosis of a variety of diseases. Various
imaging modalities have long secured their place in clinics. However, a lot of these …

Recent safety concerns surrounding the use of gadolinium-based contrast agents (GBCAs)
have spurred research into identifying alternatives to GBCAs for use with magnetic …