Heart failure with preserved ejection fraction (HFpEF) represents one of the greatest
challenges facing cardiovascular medicine today. Despite being the most common form of …

The extracellular matrix (ECM) is a living network of proteins that maintains the structural
integrity of the myocardium and allows the transmission of electrical and mechanical forces …

Objectives: The aim of this report was to show that the rate of cardiovascular events is
increased in patients with either subtype of primary aldosteronism (PA). Background …

Heart failure with preserved ejection fraction (HFpEF) is characterized by signs and
symptoms of heart failure in the presence of a normal left ventricular ejection fraction …

Cardiovascular disease is a leading cause of mortality in the world and is exacerbated by
the presence of cardiac fibrosis, defined by the accumulation of noncontractile extracellular …

Background—In arterial hypertension, left ventricular hypertrophy (LVH) includes myocyte
hypertrophy and fibrosis, which leads to LV diastolic dysfunction and, finally, heart failure. In …

Obesity is defined as excessive body fat accumulation, and worldwide obesity has nearly
tripled since 1975. Excess of free fatty acids (FFAs) and triglycerides in obese individuals …

Vascular inflammation was examined as a potential mechanism of aldosterone-mediated
myocardial injury in uninephrectomized rats receiving 1% NaCl-0.3% KCl to drink for 1, 2, or …

Background: A full understanding of the mechanisms of action of aldosterone and its
interaction with the mineralocorticoid receptor (MR) allows a theoretical framework to predict …

The importance of aldosterone in the pathophysiology of chronic heart failure (HF) has been
established in previous studies [1–4] and is emphasized by the findings of the RALES trial …