The lung is an organ that is directly exposed to the external environment. Given the large
surface area and extensive ventilation of the lung, it is prone to exposure to airborne …

The porcine model has contributed significantly to biomedical research over many decades.
The similar size and anatomy of pig and human organs make this model particularly …

Over the past 30 years, a range of cystic fibrosis (CF) animal models have been generated
for research purposes. Different species, including mice, rats, ferrets, rabbits, pigs, sheep …

The discovery of the Cystic fibrosis (CF) gene in 1989 has paved the way for incredible
progress in treating the disease such that the mean survival age of individuals living with CF …

Cystic fibrosis (CF) is a genetic disease caused by mutations in the CF transmembrane
conductance regulator (CFTR) gene. The major cause of limited life span in CF patients is …

Our understanding of the multiorgan pathology of cystic fibrosis (CF) has improved
impressively during the last decades, but we still lack a full comprehension of the disease …

Defective transepithelial electrolyte transport is thought to initiate cystic fibrosis (CF) lung
disease. Yet, how loss of CFTR affects electrolyte transport remains uncertain. CFTR−/− pigs …

Airway disease currently causes most of the morbidity and mortality in patients with cystic
fibrosis (CF). However, understanding the pathogenesis of CF lung disease and developing …

Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance
regulator (CFTR) gene. The resultant characteristic ion transport defect results in decreased …

In humans, cystic fibrosis (CF) lung disease is characterised by chronic infection,
inflammation, airway remodelling, and mucus obstruction. A lack of pulmonary …