Mycoplasma ovipneumoniae (M. ovipneumoniae) is characterized as an etiological agent of
primary atypical pneumonia that specifically infects sheep and goat. In an attempt to better …

The most common cystic fibrosis transmembrane conductance regulator (CFTR) gene
mutation is ΔF508, and this causes cystic fibrosis (CF). New CF models in the pig and ferret …

The lungs are situated at the air-blood interface and are a crucial boundary between the
organism and the environment, protecting the host from a battery of potential insults such as …

Cystic fibrosis (CF) is a life-shortening, recessive, multiorgan genetic disorder caused by the
loss of CF transmembrane conductance regulator (CFTR) chloride channel function found in …

Wnt/β-catenin-dependent activation of lymphoid enhancer factor 1 (Lef-1) plays an important
role in numerous developmental processes. In this context, transcription of the Lef-1 gene is …

Damage to the respiratory epithelium is one of the most critical steps to many life-threatening
diseases, such as acute respiratory distress syndrome and chronic obstructive pulmonary …

BACKGROUND The cystic fibrosis transmembrane conductance regulator (CFTR) plays a
critical role in electrolyte and fluid transport in epithelial cells, and women with cystic fibrosis …

Non-human primates (NHPs) are considered to be among the most relevant animal models
for pre-clinical testing of human therapies, on the basis of their close evolutionary …

We analyzed the virulence of pandemic H1N1 2009 influenza A viruses in vivo and in vitro.
Selected viruses isolated in 2009, 2010, 2014, and 2015 were assessed using an aerosol …

Key points Malfunction of the cystic fibrosis transmembrane conductance regulator (CFTR),
a gated pathway for chloride movement, causes the common life‐shortening genetic …