Activation of an innate immune response in airway epithelia by the human pathogen
Pseudomonas aeruginosa requires bacterial expression of flagellin. Addition of flagellin …

The anion channel cystic fibrosis transmembrane conductance regulator (CFTR) is a unique
ATP-binding cassette (ABC) transporter. CFTR plays a pivotal role in transepithelial ion …

Mucociliary clearance (MCC) is a critical host innate defense mechanism in airways, and it is
impaired in cystic fibrosis (CF) and other obstructive lung diseases. Epithelial fluid secretion …

Lung infection with Pseudomonas aeruginosa, leading to chronic lung disease with
impaired function, is the major course of morbidity and mortality among cystic fibrosis …

Cystic fibrosis liver disease (CFLD) is treated with ursodeoxycholate (UDCA). Our aim was
to evaluate, in cystic fibrosis transmembrane regulator knockout (Cftr−/−) mice and wild-type …

Hypersecretion of chloride can cause diarrhea, a disease frequently occurring in young pigs,
particularly around weaning. We investigated the contribution of different channels to …

Background Airway mucociliary clearance (MCC) is an important defense mechanism
against pulmonary infections and is compromised in cystic fibrosis (CF). Cl-and HCO3 …

Chronic lung infection is the main cause of morbidity and mortality in people with cystic
fibrosis (CF). For many years, it was thought that monobacterial biofilm communities mainly …

We recently created a cystic fibrosis ferret model that acquires neonatal lung infection. To
develop lung gene therapies for this model, we evaluated recombinant adeno-associated …

In the past 2 years, new gene-targeting approaches using adeno-associated virus and
designer zinc-finger nucleases have been successfully applied to the production of …