Copy number aberrations (CNAs), which are pathogenic copy number variations (CNVs),
play an important role in the initiation and progression of cancer. Single-cell DNA …

Small cell lung cancer (SCLC) is characterized by morphologic, epigenetic and
transcriptomic heterogeneity. Subtypes based upon predominant transcription factor …

Triple-negative breast cancer (TNBC) is an aggressive subtype that frequently develops
resistance to chemotherapy. An unresolved question is whether resistance is caused by the …

How cell-to-cell copy number alterations that underpin genomic instability in human cancers
drive genomic and phenotypic variation, and consequently the evolution of cancer, remains …

Ductal carcinoma in situ (DCIS) is an early-stage breast cancer that infrequently progresses
to invasive ductal carcinoma (IDC). Genomic evolution has been difficult to delineate during …

Molecular analysis of cell-free DNA (cfDNA) that circulates in plasma and other body fluids
represents a “liquid biopsy” approach for non-invasive cancer screening or monitoring. The …

Microscopy image analysis is a major bottleneck in quantification of single-cell microscopy
data, typically requiring human oversight and curation, which limit both accuracy and …

The development of targeted anti-cancer therapies through the study of cancer genomes is
intended to increase survival rates and decrease treatment-related toxicity. We treated a …

Follicular lymphoma (FL) and the GCB subtype of diffuse large B-cell lymphoma (DLBCL)
derive from germinal center B cells. Targeted resequencing studies have revealed mutations …

Chromosomal translocations are critically involved in the molecular pathogenesis of B-cell
lymphomas, and highly recurrent and specific rearrangements have defined distinct …