There are still many unanswered questions concerning viral SARS-CoV-2 pathogenesis in
COVID-19. Accessory proteins in SARS-CoV-2 consist of eleven viral proteins whose roles …

We are living through an unprecedented crisis with the rapid spread of the new coronavirus
disease (COVID-19) worldwide within a short time. The timely availability of thousands of …

Chymotrypsin-like protease (3CL pro) is a virally encoded main proteinase that is pivotal for
the viral replication across a broad spectrum of coronaviruses. This study aims to discover …

The COVID-19 pandemic has spread rapidly and poses an unprecedented threat to the
global economy and human health. Broad-spectrum antivirals are currently being …

COVID-19—a severe acute respiratory syndrome disease caused by coronavirus 2 (SARS-
CoV-2)—has recently attracted global attention, due to its devastating impact, to the point of …

Abstract Coronavirus disease 2019 (COVID-19) represents an unmet clinical need, due to a
high mortality rate, rapid mutation rate in the virus, increased chances of reinfection, lack of …

Abstract Coronavirus disease 2019 (COVID-19) caused by a novel coronavirus, severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in considerable …

Viral mRNA cap methyltransferases (MTases) are emerging targets for the development of
broad-spectrum antiviral agents. In this work, we designed potential SARS-CoV-2 MTase …

Summary SARS-CoV-2, the causative agent of the present COVID-19 pandemic, possesses
eleven accessory proteins encoded in its genome, and some have been implicated in …

COVID-19 is a pandemic respiratory disease caused by the SARS− CoV− 2 coronavirus.
The worldwide epidemiologic data showed higher mortality in males compared to females …