SARS-CoV-2 accessory proteins in viral pathogenesis: knowns and unknowns
N Redondo, S Zaldívar-López, JJ Garrido… - Frontiers in …, 2021 - frontiersin.org
There are still many unanswered questions concerning viral SARS-CoV-2 pathogenesis in
COVID-19. Accessory proteins in SARS-CoV-2 consist of eleven viral proteins whose roles …
COVID-19. Accessory proteins in SARS-CoV-2 consist of eleven viral proteins whose roles …
One year update on the COVID-19 pandemic: Where are we now?
SK Mishra, T Tripathi - Acta tropica, 2021 - Elsevier
We are living through an unprecedented crisis with the rapid spread of the new coronavirus
disease (COVID-19) worldwide within a short time. The timely availability of thousands of …
disease (COVID-19) worldwide within a short time. The timely availability of thousands of …
Discovery of naturally occurring inhibitors against SARS-CoV-2 3CLpro from Ginkgo biloba leaves via large-scale screening
Y Xiong, GH Zhu, HN Wang, Q Hu, LL Chen, XQ Guan… - Fitoterapia, 2021 - Elsevier
Chymotrypsin-like protease (3CL pro) is a virally encoded main proteinase that is pivotal for
the viral replication across a broad spectrum of coronaviruses. This study aims to discover …
the viral replication across a broad spectrum of coronaviruses. This study aims to discover …
Unraveling the mechanism of arbidol binding and inhibition of SARS-CoV-2: Insights from atomistic simulations
The COVID-19 pandemic has spread rapidly and poses an unprecedented threat to the
global economy and human health. Broad-spectrum antivirals are currently being …
global economy and human health. Broad-spectrum antivirals are currently being …
Cyanobacteria and algae-derived bioactive metabolites as antiviral agents: Evidence, mode of action, and scope for further expansion; a comprehensive review in …
COVID-19—a severe acute respiratory syndrome disease caused by coronavirus 2 (SARS-
CoV-2)—has recently attracted global attention, due to its devastating impact, to the point of …
CoV-2)—has recently attracted global attention, due to its devastating impact, to the point of …
[HTML][HTML] Therapeutic dilemmas in addressing SARS-CoV-2 infection: Favipiravir versus Remdesivir
Abstract Coronavirus disease 2019 (COVID-19) represents an unmet clinical need, due to a
high mortality rate, rapid mutation rate in the virus, increased chances of reinfection, lack of …
high mortality rate, rapid mutation rate in the virus, increased chances of reinfection, lack of …
Human genetic basis of coronavirus disease 2019
H Deng, X Yan, L Yuan - Signal transduction and targeted therapy, 2021 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) caused by a novel coronavirus, severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in considerable …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in considerable …
Potent SARS-CoV-2 mRNA cap methyltransferase inhibitors by bioisosteric replacement of methionine in SAM cosubstrate
O Bobileva, R Bobrovs, I Kanepe… - ACS Medicinal …, 2021 - ACS Publications
Viral mRNA cap methyltransferases (MTases) are emerging targets for the development of
broad-spectrum antiviral agents. In this work, we designed potential SARS-CoV-2 MTase …
broad-spectrum antiviral agents. In this work, we designed potential SARS-CoV-2 MTase …
[HTML][HTML] Impairment of antiviral immune response and disruption of cellular functions by SARS-CoV-2 ORF7a and ORF7b
T García-García, R Fernández-Rodríguez, N Redondo… - IScience, 2022 - cell.com
Summary SARS-CoV-2, the causative agent of the present COVID-19 pandemic, possesses
eleven accessory proteins encoded in its genome, and some have been implicated in …
eleven accessory proteins encoded in its genome, and some have been implicated in …
Estrogen receptor modulators in viral infections such as SARS− CoV− 2: therapeutic consequences
N Abramenko, F Vellieux, P Tesařová, Z Kejík… - International Journal of …, 2021 - mdpi.com
COVID-19 is a pandemic respiratory disease caused by the SARS− CoV− 2 coronavirus.
The worldwide epidemiologic data showed higher mortality in males compared to females …
The worldwide epidemiologic data showed higher mortality in males compared to females …