Here, we studied muscle-specific and muscle-related miRNAs in plasma of exercising
humans. Our aim was to determine whether they are affected by eccentric and/or concentric …

The spaceflight environment presents unique challenges to terrestrial biology, including but
not limited to the direct effects of gravity. As we near the end of the Space Shuttle era, there …

Rationale Muscle atrophy confers a poor prognosis in patients with chronic obstructive
pulmonary disease (COPD), yet the molecular pathways responsible are poorly …

MicroRNAs are small non-coding regulatory RNAs which may be released into the systemic
circulation as a consequence of the body's adaptation to exercise. The expression profile of …

Mechanical unloading in microgravity is thought to induce tissue degeneration by various
mechanisms, including inhibition of regenerative stem cell differentiation. To address this …

Low-grade inflammation associated with type 2 diabetes (T2DM) is postulated to exacerbate
insulin resistance. We report that serum levels, as well as IL-13 secreted from cultured …

A significant proportion of heart failure patients develop skeletal muscle wasting and cardiac
cachexia, which is associated with a very poor prognosis. Recently, myostatin, a cytokine …

The aim was to test the hypothesis that 7 days of bed rest reduces mitochondrial number
and expression and activity of oxidative proteins in human skeletal muscle but that exercise …

MicroRNAs (miRNAs) have emerged as important players in the regulation of gene
expression, being involved in most biological processes examined to date. The proposal …

Changes in skeletal muscle mass are controlled by mechanisms that dictate protein
synthesis or degradation. The current human study explored whether changes in activation …