Transcriptome response of human skeletal muscle to divergent exercise stimuli

JM Dickinson, AC D'Lugos… - Journal of Applied …, 2018 - journals.physiology.org
Aerobic (AE) and resistance exercise (RE) elicit unique adaptations in skeletal muscle that
have distinct implications for health and performance. The purpose of this study was to …

MicroRNAs in skeletal muscle and their regulation with exercise, ageing, and disease

E Zacharewicz, S Lamon, AP Russell - Frontiers in physiology, 2013 - frontiersin.org
Skeletal muscle makes up approximately 40% of the total body mass, providing structural
support and enabling the body to maintain posture, to control motor movements and to store …

Skeletal muscle atrogenes: From rodent models to human pathologies

D Taillandier, C Polge - Biochimie, 2019 - Elsevier
Skeletal muscle atrophy is a common side effect of most human diseases. Muscle loss is not
only detrimental for the quality of life but it also dramatically impairs physiological processes …

Transcriptome analysis of gravitational effects on mouse skeletal muscles under microgravity and artificial 1 g onboard environment

R Okada, S Fujita, R Suzuki, T Hayashi, H Tsubouchi… - Scientific reports, 2021 - nature.com
Spaceflight causes a decrease in skeletal muscle mass and strength. We set two murine
experimental groups in orbit for 35 days aboard the International Space Station, under …

[HTML][HTML] Essential amino acids increase microRNA-499,− 208b, and− 23a and downregulate myostatin and myocyte enhancer factor 2C mRNA expression in human …

MJ Drummond, EL Glynn, CS Fry, S Dhanani… - The Journal of …, 2009 - Elsevier
Essential amino acids (EAA) stimulate muscle protein synthesis in humans. However, little is
known about whether microRNAs (miRNA) and genes associated with muscle growth are …

[HTML][HTML] A myostatin and activin decoy receptor enhances bone formation in mice

P Bialek, J Parkington, X Li, D Gavin, C Wallace… - Bone, 2014 - Elsevier
Myostatin is a member of the bone morphogenetic protein/transforming growth factor-β
(BMP/TGFβ) super-family of secreted differentiation factors. Myostatin is a negative regulator …

Stem cell health and tissue regeneration in microgravity

E Blaber, K Sato, EAC Almeida - Stem cells and development, 2014 - liebertpub.com
Exposure to microgravity causes significant mechanical unloading of mammalian tissues,
resulting in rapid alterations of their physiology, which poses a significant risk for long …

Posttranscriptional mechanisms involving microRNA-27a and b contribute to fast-specific and glucocorticoid-mediated myostatin expression in skeletal muscle

DL Allen, AS Loh - American Journal of Physiology-Cell …, 2011 - journals.physiology.org
Expression of the antigrowth factor myostatin (MSTN) differs between fast and slow skeletal
muscles and is increased in nearly every form of muscle atrophy, but the contribution of …

Circulating miR-1, miR-133a, and miR-206 levels are increased after a half-marathon run

CPC Gomes, GP Oliveira-Jr, B Madrid, JA Almeida… - Biomarkers, 2014 - Taylor & Francis
Context: Circulating miRNAs are potential biomarkers that can be important molecules
driving cell-to-cell communication. Objective: To investigate circulating muscle-specific …

[HTML][HTML] Macrophages protect against muscle atrophy and promote muscle recovery in vivo and in vitro: a mechanism partly dependent on the insulin-like growth factor …

N Dumont, J Frenette - The American journal of pathology, 2010 - Elsevier
Hindlimb unloading and reloading are characterized by a major loss of muscle force and are
associated with classic leukocyte infiltration during recovery from muscle atrophy …