miRNAs (microRNAs) are novel post-transcriptional regulators of gene expression. Several
miRNAs, expressed exclusively in muscle, play important roles during muscle development …

There are both theoretical and empirical underpinnings that provide evidence that the
musculoskeletal system develops, functions, and ages as a whole. Thus, the risk of …

Microgravity exposure as well as chronic disuse are two main causes of skeletal muscle
atrophy in animals and humans. The antigravity calf soleus is a reference postural muscle to …

Maintenance of skeletal muscle mass and function is an incredibly nuanced balance of
anabolism and catabolism that can become distorted within different pathological conditions …

Skeletal muscle is capable of changing its structural parameters, metabolic rate and
functional characteristics within a wide range when adapting to various loading regimens …

Microgravity exposure is associated with loss of muscle mass and strength. The E3 ubiquitin
ligase MuRF1 plays an integral role in degrading the contractile apparatus of skeletal …

Epigenetic mechanisms regulate muscle mass and function in models of muscle dysfunction
and atrophy. We assessed whether quadriceps muscle weakness and atrophy are …

The circadian clock regulates cellular and molecular processes in mammals across all
tissues including skeletal muscle, one of the largest organs in the human body …

Over the last decade non-coding RNAs have emerged as importance regulators of gene
expression. In particular, microRNAs are a class of small RNAs of~ 22 nucleotides that …

Spaceflight introduces a combination of environmental stressors, including microgravity,
ionizing radiation, changes in diet and altered atmospheric gas composition. In order to …