MicroRNAs (miRNAs) are short, non-coding RNA molecules that fine tune
posttranscriptional protein expression. Aging is accompanied by progressive declines in …

Animal models are useful for exploring the health consequences of prolonged spaceflight.
Capabilities were developed to perform experiments in low earth orbit with on-board sample …

Novel treatments for muscle wasting are of significant value to patients with disease states
that result in muscle weakness, injury recovery after immobilization and bed rest, and for …

MicroRNAs (miRNAs) are a class of small non-coding RNAs that have emerged as potential
predictive, prognostic, and therapeutic biomarkers, relevant to many pathophysiological …

Abstract Space is a hostile environment characterized by high vacuum, extreme
temperatures, meteoroids, space debris, ionospheric plasma, microgravity and space …

Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) through binding to its
receptor fibroblast growth factor inducible 14 (Fn14) has been shown to regulate many …

Spaceflight exerts an extreme and unique influence on human physiology as astronauts are
subjected to long-term or short-term exposure to microgravity. During spaceflight, a multitude …

ABSTRACT A large body of evidence indicates modified expression of protein-coding genes
in response to different kinds of physical activity. Recent years have exposed another level …

Microgravity exposure causes several physiological and psychosocial alterations that
challenge astronauts' health during space flight. Notably, many of these changes are mostly …

Myostatin (MSTN) is member of the transforming growth factor β (TGF-β) superfamily and
was originally identified in the musculoskeletal system as a negative regulator of skeletal …