The clearance of apoptotic cells by professional and non-professional phagocytes—a
process termed 'efferocytosis'—is essential for the maintenance of tissue homeostasis …

Genome-wide association studies and functional genomics studies have linked specific cell
types, genes, and pathways to Alzheimer's disease (AD) risk. In particular, AD risk alleles …

Metastasis is the leading cause of cancer-related deaths, and greater knowledge of the
metastatic microenvironment is necessary to effectively target this process …

Distinct macrophage populations throughout the body display highly heterogeneous
transcriptional and epigenetic programs. Recent research has highlighted that these profiles …

During atherosclerosis, the gradual accumulation of lipids into the subendothelial space of
damaged arteries results in several lipid modification processes followed by macrophage …

Since the pioneering work of Elie Metchnikoff and the discovery of cellular immunity, the
phagocytic clearance of cellular debris has been considered an integral component of …

Ketocholesterol (7KC) is a toxic oxysterol that is associated with many diseases and
disabilities of aging, as well as several orphan diseases. 7KC is the most common product of …

Neutrophils are first-responders, providing early protection against invading pathogens.
Recent findings have revealed a temporal dimension to neutrophil function, associated with …

Understanding the cellular composition of the tumor microenvironment and the interactions
of the cells is essential to the development of successful immunotherapies in cancer. We …

Macrophages are the primary targets of Mycobacterium tuberculosis infection; the early
events of macrophage interaction with M. tuberculosis define subsequent progression and …