To study the role of IL‐12 as a third signal for T‐cell activation and differentiation in vivo,
direct IL‐12 signaling to CD8+ T cells was analyzed in bacterial and viral infections using …

Listeria monocytogenes (Lm) infection induces robust CD8 T cell responses, which play a
critical role in resolving Lm during primary infection and provide protective immunity to re …

Establishing functional tissue-resident memory (TRM) cells at sites of infection is a newfound
objective of T cell vaccine design. To directly assess the impact of antigen stimulation …

Sepsis is the leading cause of death in most intensive care units, and patients who survive
the hyperinflammation that develops early during sepsis later display severely compromised …

Immunological memory, defined as the ability to respond in an enhanced manner upon
secondary encounter with the same pathogen, can provide substantial protection against …

During an immune response against a microbial pathogen, activated naive T lymphocytes
give rise to effector cells that provide acute host defense and memory cells that provide long …

During primary Ag encounter, T cells receive numerous positive and negative signals that
control their proliferation, function, and differentiation, but how these signals are integrated …

Generating a large population of memory CD8 T cells is an appealing goal for vaccine
design against a variety of human diseases. Indeed, experimental models have …

Vaccines, arguably the single most important intervention in improving human health, have
exploited the phenomenon of immunological memory. The elicitation of memory T cells is …

As effector memory T cells (Tem) are the predominant population elicited by chronic
parasitic infections, increasing our knowledge of their function, survival and derivation, as …