[HTML][HTML] Progress in bioengineering strategies for heart regenerative medicine

T Häneke, M Sahara - International Journal of Molecular Sciences, 2022 - mdpi.com
The human heart has the least regenerative capabilities among tissues and organs, and
heart disease continues to be a leading cause of mortality in the industrialized world with …

[HTML][HTML] New developments in exosomal lncRNAs in cardiovascular diseases

Z Yuan, W Huang - Frontiers in Cardiovascular Medicine, 2021 - frontiersin.org
Long non-coding RNAs (lncRNAs) are non-coding RNAs with lengths> 200 nt and are
involved in the occurrence and development of cardiovascular diseases (CVDs). Exosomes …

[HTML][HTML] The role of epigenetics in congenital heart disease

TB Lim, SYR Foo, CK Chen - Genes, 2021 - mdpi.com
Congenital heart disease (CHD) is the most common birth defect among newborns
worldwide and contributes to significant infant morbidity and mortality. Owing to major …

[HTML][HTML] Novel applications of mesenchymal stem cell-derived exosomes for myocardial infarction therapeutics

SJ Ozaki Tan, JF Floriano, L Nicastro, C Emanueli… - Biomolecules, 2020 - mdpi.com
Cardiovascular diseases (CVDs) are the leading cause of mortality and morbidity globally,
representing approximately a third of all deaths every year. The greater part of these cases …

[HTML][HTML] Human adipose-derived stem cells enriched with VEGF-modified mRNA promote angiogenesis and long-term graft survival in a fat graft transplantation model

F Yu, N Witman, D Yan, S Zhang, M Zhou… - Stem cell research & …, 2020 - Springer
Background Fat grafting, as a standard treatment for numerous soft tissue defects, remains
unpredictable and technique-dependent. Human adipose-derived stem cells (hADSCs) are …

[HTML][HTML] Retinoic acid signaling modulation guides in vitro specification of human heart field-specific progenitor pools

D Zawada, J Kornherr, AB Meier, G Santamaria… - Nature …, 2023 - nature.com
Cardiogenesis relies on the precise spatiotemporal coordination of multiple progenitor
populations. Understanding the specification and differentiation of these distinct progenitor …

WNT/β‐catenin pathway is a key regulator of cardiac function and energetic metabolism

VV Balatskyi, A Sowka, P Dobrzyn… - Acta …, 2023 - Wiley Online Library
The WNT/β‐catenin pathway is a master regulator of cardiac development and growth, and
its activity is low in healthy adult hearts. However, even this low activity is essential for …

[HTML][HTML] Placental growth factor exerts a dual function for cardiomyogenesis and vasculogenesis during heart development

N Witman, C Zhou, T Häneke, Y Xiao, X Huang… - Nature …, 2023 - nature.com
Cardiogenic growth factors play important roles in heart development. Placental growth
factor (PLGF) has previously been reported to have angiogenic effects; however, its potential …

Regenerative medicine: prenatal approaches

P de Coppi, S Loukogeorgakis… - The Lancet Child & …, 2022 - thelancet.com
This two-paper Series focuses on recent advances and applications of regenerative
medicine that could benefit paediatric patients. Innovations in genomic, stem-cell, and tissue …

Mending a broken heart: In vitro, in vivo and in silico models of congenital heart disease

AJ Rufaihah, CK Chen, CH Yap… - Disease Models & …, 2021 - journals.biologists.com
Birth defects contribute to∼ 0.3% of global infant mortality in the first month of life, and
congenital heart disease (CHD) is the most common birth defect among newborns …