[HTML][HTML] Progress in bioengineering strategies for heart regenerative medicine
T Häneke, M Sahara - International Journal of Molecular Sciences, 2022 - mdpi.com
The human heart has the least regenerative capabilities among tissues and organs, and
heart disease continues to be a leading cause of mortality in the industrialized world with …
heart disease continues to be a leading cause of mortality in the industrialized world with …
[HTML][HTML] New developments in exosomal lncRNAs in cardiovascular diseases
Z Yuan, W Huang - Frontiers in Cardiovascular Medicine, 2021 - frontiersin.org
Long non-coding RNAs (lncRNAs) are non-coding RNAs with lengths> 200 nt and are
involved in the occurrence and development of cardiovascular diseases (CVDs). Exosomes …
involved in the occurrence and development of cardiovascular diseases (CVDs). Exosomes …
[HTML][HTML] The role of epigenetics in congenital heart disease
Congenital heart disease (CHD) is the most common birth defect among newborns
worldwide and contributes to significant infant morbidity and mortality. Owing to major …
worldwide and contributes to significant infant morbidity and mortality. Owing to major …
[HTML][HTML] Novel applications of mesenchymal stem cell-derived exosomes for myocardial infarction therapeutics
Cardiovascular diseases (CVDs) are the leading cause of mortality and morbidity globally,
representing approximately a third of all deaths every year. The greater part of these cases …
representing approximately a third of all deaths every year. The greater part of these cases …
[HTML][HTML] Human adipose-derived stem cells enriched with VEGF-modified mRNA promote angiogenesis and long-term graft survival in a fat graft transplantation model
F Yu, N Witman, D Yan, S Zhang, M Zhou… - Stem cell research & …, 2020 - Springer
Background Fat grafting, as a standard treatment for numerous soft tissue defects, remains
unpredictable and technique-dependent. Human adipose-derived stem cells (hADSCs) are …
unpredictable and technique-dependent. Human adipose-derived stem cells (hADSCs) are …
[HTML][HTML] Retinoic acid signaling modulation guides in vitro specification of human heart field-specific progenitor pools
D Zawada, J Kornherr, AB Meier, G Santamaria… - Nature …, 2023 - nature.com
Cardiogenesis relies on the precise spatiotemporal coordination of multiple progenitor
populations. Understanding the specification and differentiation of these distinct progenitor …
populations. Understanding the specification and differentiation of these distinct progenitor …
WNT/β‐catenin pathway is a key regulator of cardiac function and energetic metabolism
VV Balatskyi, A Sowka, P Dobrzyn… - Acta …, 2023 - Wiley Online Library
The WNT/β‐catenin pathway is a master regulator of cardiac development and growth, and
its activity is low in healthy adult hearts. However, even this low activity is essential for …
its activity is low in healthy adult hearts. However, even this low activity is essential for …
[HTML][HTML] Placental growth factor exerts a dual function for cardiomyogenesis and vasculogenesis during heart development
N Witman, C Zhou, T Häneke, Y Xiao, X Huang… - Nature …, 2023 - nature.com
Cardiogenic growth factors play important roles in heart development. Placental growth
factor (PLGF) has previously been reported to have angiogenic effects; however, its potential …
factor (PLGF) has previously been reported to have angiogenic effects; however, its potential …
Regenerative medicine: prenatal approaches
P de Coppi, S Loukogeorgakis… - The Lancet Child & …, 2022 - thelancet.com
This two-paper Series focuses on recent advances and applications of regenerative
medicine that could benefit paediatric patients. Innovations in genomic, stem-cell, and tissue …
medicine that could benefit paediatric patients. Innovations in genomic, stem-cell, and tissue …
Mending a broken heart: In vitro, in vivo and in silico models of congenital heart disease
Birth defects contribute to∼ 0.3% of global infant mortality in the first month of life, and
congenital heart disease (CHD) is the most common birth defect among newborns …
congenital heart disease (CHD) is the most common birth defect among newborns …