Specific IL-1 family cytokines are expressed by cells as cytosolic pro-forms that require
cleavage for their activity and cellular release. IL-1β, IL-18, and IL-37 maturation and …

Inflammasomes are macromolecular platforms formed in response to damage-associated
molecular patterns (DAMPs) and pathogen-associated molecular patterns, whose formation …

Microglia and neuroinflammation play an important role in the development and progression
of Alzheimer's disease (AD). Inositol polyphosphate-5-phosphatase D (INPP5D/SHIP1) is a …

Fungal pathogens kill approximately 1.5 million individuals per year and represent a severe
disease burden worldwide. It is estimated over 150 million people have serious fungal …

Abstract Background and Hypothesis Immune activation is suggested to play an important
role in psychosis. In this study, a large number of immune-related proteins were analyzed to …

Inflammasomes are cytosolic multiprotein complexes that crucially contribute to host defense
against pathogens but are also involved in the pathogenesis of autoinflammatory diseases …

Highlights•Fungal recognition by C-type lectin receptors are critical for proper immune
response.•Innate effector pathways contribute to fungal killing and recruit immune cells.•CLR …

Alcoholic liver disease (ALD) is caused by long-term consumption of alcohol and has
become an important social and medical problem. Intestinal fungal flora (mycobiota) play an …

The granulomatous lesion resulting from infection with the fungus Paracoccidioides
brasiliensis is characterized by a compact aggregate of mature cells, surrounded by a …

Earlier studies indicate that either the canonical or non-canonical pathways of
inflammasome activation have a limited role on malaria pathogenesis. Here, we report that …