The hormonal metabolite of vitamin D, 1α, 25-dihydroxyvitamin D 3 (1, 25D), initiates
biological responses via binding to the vitamin D receptor (VDR). When occupied by 1, 25D …

Cytosine DNA methylation is a stable epigenetic mark that is crucial for diverse biological
processes, including gene and transposon silencing, imprinting and X chromosome …

Significant controversy has emerged over the last decade concerning the effects of vitamin D
on skeletal and nonskeletal tissues. The demonstration that the vitamin D receptor is …

The term epigenetics was first used to refer to the complex interactions between the genome
and the environment that are involved in development and differentiation in higher …

Epigenetic modifications are heritable changes in gene expression not encoded by the DNA
sequence. In the past decade, great strides have been made in characterizing epigenetic …

Thymine DNA glycosylase (TDG) excises T from G· T mispairs and is thought to initiate base
excision repair (BER) of deaminated 5-methylcytosine (mC). Recent studies show that TDG …

The conformationally flexible secosteroid, 1α, 25 (OH) 2vitamin D3 (1α, 25 (OH) 2D3)
initiates biological responses via binding to the vitamin D receptor (VDR). The VDR contains …

The vitamin D signal transduction system involves a series of cytochrome P450-containing
sterol hydroxylases to generate and degrade the active hormone, 1α, 25-dihydroxyvitamin D …

DNA methylation is a major epigenetic mechanism for gene silencing. Whereas
methyltransferases mediate cytosine methylation, it is less clear how unmethylated regions …

DNA methylation is one of the best-characterized epigenetic modifications and has been
implicated in numerous biological processes, including transposable element silencing …