Alzheimer's disease (AD) is a complex, heterogeneous, progressive disease and is the most
common type of neurodegenerative dementia. The prevalence of AD is expected to increase …

Abstract In 2011, the National Institute on Aging and Alzheimer's Association created
separate diagnostic recommendations for the preclinical, mild cognitive impairment, and …

It is currently unclear how amyloid-β and tau deposition are linked to changes in synaptic
function and axonal structure over the course of Alzheimer's disease. Here, we assessed …

During the past decade, a conceptual shift occurred in the field of Alzheimer's disease (AD)
considering the disease as a continuum. Thanks to evolving biomarker research and …

Aging is a natural process that is associated with cognitive decline as well as functional and
social impairments. One structure of particular interest when considering aging and …

See Sarazin et al.(doi: 10.1093/brain/aww041) for a scientific commentary on this article.
The advent of the positron emission tomography tracer 18 F-AV1451 provides the unique …

This article reviews the cognitive changes that occur with normal aging, the structural and
functional correlates of these cognitive changes, and the prevalence and cognitive effects of …

There is a need for new therapeutic targets with which to prevent Alzheimer's disease (AD),
a major contributor to aging-related cognitive decline. Here we report the construction and …

Importance A National Institute on Aging–Alzheimer's Association (NIA-AA) workgroup
recently published a research framework in which Alzheimer disease is defined by …

The prevalence of dementia is increasing in our aging population at an alarming rate.
Because of the heterogeneity of clinical presentation and complexity of disease …