Prior to the SARS-CoV-2 pandemic, antibiotic resistance was listed as the major global
health care priority. Some analyses, including the O'Neill report, have predicted that deaths …

Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host
response to infection. In this context, biomarkers could be considered as indicators of either …

The genus Cryptococcus contains two primary species complexes that are significant
opportunistic human fungal pathogens: C. neoformans and C. gattii. In humans …

Background Patients without human immunodeficiency virus (HIV) are increasingly
recognized as being at risk for cryptococcosis. Knowledge of characteristics of …

Purpose Metagenomic next-generation sequencing (mNGS) has been widely used to
diagnose infectious diseases. However, there are few studies on its diagnostic performance …

Background The incidence of cryptococcosis amongst HIV-negative persons is increasing.
Whilst the excellent performance of the CrAg testing in people living with HIV is well …

Because of the vast numbers of COVID-19 infections, IFD in COVID-19 critical-care patients
represents a significant burden of disease, even if incidences are less than 5%. Optimal …

Introduction Central nervous system infections (CNSI) disproportionately affect individuals in
low-resource settings where diagnosis is challenging; large proportions of patients never …

Background Despite expanded access to antiretroviral therapy (ART) and the rollout of the
World Health Organization's (WHO)'test‐and‐treat'strategy, the proportion of people with HIV …

Objectives Histoplasmosis and cryptococcosis are important public health problems in
people living with HIV (PLHIV) in Central America. Conventional laboratory assays, based …