Senescence is a cellular response to a variety of stress signals that is characterized by a
stable withdrawal from the cell cycle and major changes in cell morphology and physiology …

Engineering a patient's own T cells to selectively target and eliminate tumour cells has cured
patients with untreatable haematologic cancers. These results have energized the field to …

The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast complexity
of cancer phenotypes and genotypes into a provisional set of underlying principles. As …

Cellular senescence is a hallmark of aging defined by stable exit from the cell cycle in
response to cellular damage and stress. Senescent cells (SnCs) can develop a …

Ageing organisms accumulate senescent cells that are thought to contribute to body
dysfunction. Telomere shortening and damage are recognized causes of cellular …

Polyunsaturated fatty acids (PUFAs) are structural components of membrane phospholipids,
and influence cellular function via effects on membrane properties, and also by acting as a …

Traditional views of cellular metabolism imply that it is passively adapted to meet the
demands of the cell. It is becoming increasingly clear, however, that metabolites do more …

Ageing leads to profound alterations in the immune system and increases susceptibility to
some chronic, infectious and autoimmune diseases. In recent years, widespread application …

Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in
response to various intrinsic and extrinsic stimuli, as well as developmental signals …

Intervertebral disc degeneration is highly prevalent within the elderly population and is a
leading cause of chronic back pain and disability. Due to the link between disc degeneration …