Alzheimer's disease is understood to be caused by amyloid fibrils and oligomers formed by
aggregated amyloid-β (Aβ) peptides. This review article presents molecular dynamics (MD) …

Inhibiting the aggregation of amyloid peptides with endogenous peptides has broad interest
due to their intrinsically high biocompatibility and low immunogenicity. Here, we investigated …

It is known that oligomers of amyloid-β (Aβ) peptide are associated with Alzheimer's disease.
Aβ has two isoforms: Aβ40 and Aβ42. Although the difference between Aβ40 and Aβ42 is …

The cause of Alzheimer's disease is related to aggregates such as oligomers and amyloid
fibrils consisting of amyloid-β (Aβ) peptides. Molecular dynamics (MD) simulation studies …

Amyloid-β (Aβ) dimer as the smallest oligomer has recently been drawing attention due to its
neurotoxicity, transient nature, and heterogeneity. The inhibition of Aβ dimer's aggregation is …

We propose the replica permutation with solute tempering (RPST) by combining the replica-
permutation method (RPM) and the replica exchange with solute tempering (REST) …

Polyalanine (polyA) disease-causative proteins with an expansion of alanine repeats can be
aggregated. Although curative treatments for polyA diseases have not been explored, the …

Amyloidosis is known to be caused by the deposition of amyloid fibrils into various biological
tissues; effective treatments for the disease are little established today. An infrared free …

The present study employs a blend of molecular dynamics simulations and a theoretical
model to explore the potential disintegration mechanism of a matured Aβ octamer, aiming to …

Bacterial infections pose a severe threat to human health due to the exacerbation of
antibiotic resistance and intracellular bacterial infections. Research suggests that oligo (p …