[HTML][HTML] The P2X7 receptor as regulator of T cell development and function
F Grassi - Frontiers in immunology, 2020 - frontiersin.org
Unique structural features characterize the P2X7 receptor with respect to other P2X family
members. Dual gating by eATP and regulated expression of P2X7 can imprint distinct …
members. Dual gating by eATP and regulated expression of P2X7 can imprint distinct …
[PDF][PDF] Targeted delivery of immunomodulators to lymph nodes
Active-targeted delivery to lymph nodes represents a major advance toward more effective
treatment of immune-mediated disease. The MECA79 antibody recognizes peripheral node …
treatment of immune-mediated disease. The MECA79 antibody recognizes peripheral node …
[HTML][HTML] P2X7 receptor at the crossroads of T cell fate
E Rivas-Yáñez, C Barrera-Avalos… - International Journal of …, 2020 - mdpi.com
The P2X7 receptor is a ligand-gated, cation-selective channel whose main physiological
ligand is ATP. P2X7 receptor activation may also be triggered by ARTC2. 2-dependent ADP …
ligand is ATP. P2X7 receptor activation may also be triggered by ARTC2. 2-dependent ADP …
[HTML][HTML] The P2X7 receptor antagonist, oxidized adenosine triphosphate, ameliorates renal ischemia-reperfusion injury by expansion of regulatory T cells
TY Koo, JG Lee, JJ Yan, JY Jang, KD Ju, M Han… - Kidney international, 2017 - Elsevier
Extracellular adenosine triphosphate (ATP) binds to purinergic receptors and, as a danger
molecule, promotes inflammatory responses. Here we tested whether periodate-oxidized …
molecule, promotes inflammatory responses. Here we tested whether periodate-oxidized …
[HTML][HTML] To inhibit or enhance? Is there a benefit to positive allosteric modulation of P2X receptors?
The family of ligand-gated ion channels known as P2X receptors were discovered several
decades ago. Since the cloning of the seven P2X receptors (P2X1-P2X7), a huge research …
decades ago. Since the cloning of the seven P2X receptors (P2X1-P2X7), a huge research …
The dark side of extracellular ATP in kidney diseases
Intracellular ATP is the most vital source of cellular energy for biologic systems, whereas
extracellular ATP is a multifaceted mediator of several cell functions via its interaction, in an …
extracellular ATP is a multifaceted mediator of several cell functions via its interaction, in an …
Should IFN-γ, IL-17 and IL-2 be considered predictive biomarkers of acute rejection in liver and kidney transplant? Results of a multicentric study
Acute rejection (AR) remains a major challenge in organ transplantation, and there is a need
for predictive biomarkers. In the present multicenter study, we prospectively examined a …
for predictive biomarkers. In the present multicenter study, we prospectively examined a …
[HTML][HTML] DAMP—induced allograft and tumor rejection: The circle is closing
The pathophysiological importance of the immunogenicity of damage-associated molecular
patterns (DAMPs) has been pinpointed by their identification as triggers of allograft rejection …
patterns (DAMPs) has been pinpointed by their identification as triggers of allograft rejection …
[HTML][HTML] The P2X7 receptor: shifting from a low-to a high-conductance channel—an enigmatic phenomenon?
LA Alves, RA de Melo Reis, CAM de Souza… - … et Biophysica Acta (BBA …, 2014 - Elsevier
The general structure of the P2X7 receptor (P2X7R) is similar to the structure of other P2X
receptor family members, with the exception of its C terminus, which is the longest of this …
receptor family members, with the exception of its C terminus, which is the longest of this …
[HTML][HTML] Involvement of P2X7 receptor signaling on regulating the differentiation of Th17 cells and type II collagen-induced arthritis in mice
ZD Fan, YY Zhang, YH Guo, N Huang, HH Ma… - Scientific reports, 2016 - nature.com
Abstract Interleukin (IL)-17 producing T helper (Th17) cells are major effector cells in the
pathogenesis of rheumatoid arthritis (RA). The P2X7 receptor (P2X7R) has emerged as a …
pathogenesis of rheumatoid arthritis (RA). The P2X7 receptor (P2X7R) has emerged as a …