Tissue reservoirs of HIV

JK Wong, SA Yukl - Current Opinion in HIV and AIDS, 2016 - journals.lww.com
The retention of infected cells in a wide variety of tissues, often with distinct viral and cellular
characteristics, underscores the importance of studying tissue reservoirs in the development …

The role of macrophages in HIV-1 persistence and pathogenesis

Z Kruize, NA Kootstra - Frontiers in microbiology, 2019 - frontiersin.org
Current antiretroviral therapy (ART) effectively suppresses Human Immunodeficiency Virus
type 1 (HIV-1) in infected individuals. However, even long term ART does not eradicate HIV …

Historical perspective on the discovery of the quasispecies concept

E Domingo, C García-Crespo… - Annual review of …, 2021 - annualreviews.org
Viral quasispecies are dynamic distributions of nonidentical but closely related mutant and
recombinant viral genomes subjected to a continuous process of genetic variation …

Human immunodeficiency virus type 2

JD Reeves, RW Doms - Journal of general virology, 2002 - microbiologyresearch.org
The AIDS pandemic continues to spread unchecked in many parts of the world, with greater
than 34 million individuals currently infected with human immunodeficiency virus (HIV) …

Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteers

CW Hendrix, C Flexner, RT MacFarland… - Antimicrobial agents …, 2000 - Am Soc Microbiol
ABSTRACT AMD-3100, a bicyclam, is a novel agent that uniquely inhibits the entry of
human immunodeficiency virus type 1 (HIV-1) into CD4+ T cells via selective blockade of the …

Viruses in the mammalian male genital tract and their effects on the reproductive system

N Dejucq, B Jégou - Microbiology and molecular biology reviews, 2001 - Am Soc Microbiol
This review describes the various viruses identified in the semen and reproductive tracts of
mammals (including humans), their distribution in tissues and fluids, their possible cell …

Selective CXCR4 antagonism by Tat: Implications for in vivo expansion of coreceptor use by HIV-1

H Xiao, C Neuveut, HL Tiffany… - Proceedings of the …, 2000 - National Acad Sciences
Chemokines and chemokine receptors play important roles in HIV-1 infection and tropism.
CCR5 is the major macrophage-tropic coreceptor for HIV-1 whereas CXC chemokine …

Contribution of immune activation to the pathogenesis and transmission of human immunodeficiency virus type 1 infection

SD Lawn, ST Butera, TM Folks - Clinical microbiology reviews, 2001 - Am Soc Microbiol
The life cycle of human immunodeficiency virus type 1 (HIV-1) is intricately related to the
activation state of the host cells supporting viral replication. Although cellular activation is …

HIV/Mtb co-infection: from the amplification of disease pathogenesis to an “emerging syndemic”

JM Azevedo-Pereira, D Pires, M Calado, M Mandal… - Microorganisms, 2023 - mdpi.com
Human immunodeficiency virus (HIV) and Mycobacterium tuberculosis (Mtb) are pathogens
responsible for millions of new infections each year; together, they cause high morbidity and …

HIV-1 pathogenesis: the virus

R Swanstrom, J Coffin - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Transmission of HIV-1 results in the establishment of a new infection, typically starting from a
single virus particle. That virion replicates to generate viremia and persistent infection in all …