Control of blood flow distribution and tissue homeostasis depend on the tight regulation of
and coordination between the microvascular network and circulating blood cells. Channels …

Sepsis represents a global health concern, and patients with severe sepsis are at risk of
experiencing MODS (multiple organ dysfunction syndrome), which is associated with …

Inflammatory cell recruitment to local sites of tissue injury and/or infection is controlled by a
plethora of signalling processes influencing cell-to-cell interactions between the vascular …

Rationale: Resistant hypertension is a major health concern with unknown cause.
Spironolactone is an effective antihypertensive drug, especially for patients with resistant …

Vitamin D deficiency is one of the most common nutritional deficiencies worldwide. Maternal
vitamin D deficiency is associated with increased susceptibility to hypertension in offspring …

Microcirculation homeostasis depends on several channels permeable to ions and/or small
molecules that facilitate the regulation of the vasomotor tone, hyperpermeability, the blood …

An exaggerated inflammatory response is the hallmark of a plethora of disorders. ATP is a
central signaling molecule that orchestrates the initiation and resolution of the inflammatory …

Adult skeletal muscle has robust regenerative capabilities due to the presence of a resident
stem cell population called satellite cells. Muscle injury leads to these normally quiescent …

Deletion of pannexin‐1 (Panx‐1) leads not only to a reduction in endothelium‐derived
hyperpolarization but also to an increase in NO‐mediated vasodilation. Therefore, we …

Background Gap junctions (GJ) are one of the most common forms of intercellular
communication. GJs are assembled from proteins that form channels connecting the …