COVID-19 can be divided into three clinical stages, and one can speculate that these stages
correlate with where the infection resides. For the asymptomatic phase, the infection mostly …

The alveolar epithelium consists of (ATI) and type II (ATII) cells. ATI cells cover the majority of
the alveolar surface due to their thin, elongated shape and are largely responsible for barrier …

The cell type specific sequences of transcriptional programs during lung regeneration have
remained elusive. Using time-series single cell RNA-seq of the bleomycin lung injury model …

Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease arising from impaired
regeneration of the alveolar epithelium after injury. During regeneration, type 2 alveolar …

Stem cells undergo dynamic changes in response to injury to regenerate lost cells.
However, the identity of transitional states and the mechanisms that drive their trajectories …

Regeneration of the architecturally complex alveolar niche of the lung requires precise
temporal and spatial control of epithelial cell behavior. Injury can lead to a permanent …

Impaired differentiation of alveolar stem cells has been identified in a variety of acute and
chronic lung diseases. In this study, we investigate the mechanisms that modulate alveolar …

Tissue regeneration is a multi-step process mediated by diverse cellular hierarchies and
states that are also implicated in tissue dysfunction and pathogenesis. Here we leveraged …

Alveolar epithelial regeneration is essential for recovery from devastating lung diseases.
This process occurs when type II alveolar pneumocytes (AT2 cells) proliferate and …

Summary Wnt ligands oligomerize Frizzled (Fzd) and Lrp5/6 receptors to control the
specification and activity of stem cells in many species. How Wnt signaling is selectively …